Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;...
Patent
1992-09-11
1995-11-14
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
435189, 4352831, 435808, 435817, 530385, 530401, 530810, 422 57, 422 70, 422 76, 422 8201, 422 8205, C12N 1102, C12M 114, G01N 27327, G01N 2141
Patent
active
054665892
ABSTRACT:
The present invention is directed to coated substrates having a coating of biological macromolecules, preferably proteins, which are capable of being immobilized on a substrate surface and have a marker. These proteins usually are mutant proteins obtained by mutagenesis of the gene encoding a random positioning protein. When a mutant protein molecule is immobilized on the substrate, the marker of the mutant protein molecule is in a select spatial relationship with both the substrate and the markers of adjacent protein molecules. A substrate coated with an oriented layer of the mutant proteins exhibits improved or different properties when compared to a substrate having a randomly positioned layer of proteins thereon.
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Bohn Paul W.
McLean Mark A.
Olinger Jill M.
Sligar Stephen G.
Stayton Patrick
Biotechnology Research & Development Corporation
Walsh Stephen G.
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