Coated solid medicament form having releasability in large intes

Details Coated solid medicament form having releasability in large intes Coated solid medicament form having releasability in large intes

1991-07-08

1993-06-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424458, 424461, 424479, 424482, 424493, 424494, 514960, 514887, A61K 936

Patent

active

052177203

ABSTRACT:
A coated solid medicament form suitable for oral administration having reliable releasability of the active ingredient only in the large intestine is proposed. The medicament form is prepared by coating a core solid medicament form containing the active ingredient first with a chitosan having a specific degree of deacetylation and a specific degree of polymerization and then top-coated with a specific enteric-soluble polymer which is a hydroxypropyl methyl cellulose acetate succinate or a hydroxypropyl methyl cellulose hexahydrophthalate. The releasability of the active ingredient only in the large intestine can be more reliable when the core medicament form is, prior to coating with chitosan, provided with an enteric undercoating layer.

REFERENCES:
patent: 4432966 (1984-02-01), Zeitoun et al.
patent: 4876097 (1989-10-01), Autant et al.

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