Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer
Patent
1994-04-18
1996-02-20
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Aftertreated polymer
514967, 514843, 128918, A61K 4732, A61K 31085
Patent
active
054926920
ABSTRACT:
A composition which has potent anti-HIV activity. The composition is a high energy coprecipitate of nonoxynol-9 oligomers, polyvinyl-pyrrolidone (PVP) and iodine or PVP-I and shows a pronounced synergistic, anti-HIV effect between the compounds of the composition. The invention also includes paper and plastic products coated with the composition of the invention.
REFERENCES:
patent: 4954351 (1990-09-01), Sackler et al.
patent: 5070889 (1991-12-01), Leveen et al.
Lancet 12/21 (1985/pp. 1422-1423 Hicks et al.
Simonelli et al. (1987) Proceed. of the 2nd Int. Symp. on Povidone Digenis et al. (1987) pp. 392-401.
Voeller, B. "Nonoxynol-9 and HTLV-III", Lancet (1986) 1153.
Malkovsky, M. et al, "Inactivation of HIV by Nonoxynol-9", Lancet (1988) 645.
Liebert, M. A. "Final Report on the Safety Assessment of nonoxynols -2, -4, -8, -9, -10, -12, -14, -15, -30, -40, and -50", J. Am. Coll. Toxicol. (1983) 2:35-60.
Chvapil, M. et al. "Studies on Nonoxynol-9. III. Effect on Fibroblasts and Spermatozoa", Fertil. Steril. (1980) 33:521-525.
Knaak, J. B. et al. "Excretion of Certain Polyethylene Glycol Ether Adducts of Nonylphenol by the Rat", Toxicol. Appl. Pharmacol. (1966) 9:331-340.
Walter, B. A. et al. "Disposition of [.sup.14 C] Nonoxynol-9 After Intravenous of Vaginal Administration to Female Sprague-Dawley Rats", Toxicol. Applied Pharmacol. (1988) 96:258-268.
Walter, B. A. et al. "High-Performance Liquid Chromatographic (HPLC) Analysis of Oligomeric Components of Spermicide Nonoxynol-9", Pharm. Res. (1991) 8:409-411.
Walter, B. A. et al. "Solubilization and in Vitro Spermicidal Assessment of Nonoxynol-9 and Selected Fractions Using Rabbit Spermatozoa", Pharm. Res. (1991) 8:403-408.
Higuchi, W. I. et al. "Drug Membrane Transport Enhancement Using High Energy Drug-Povidone Coprecipitates", Proceedings of the International Symposium on Povidione, Digenis, G. A. and Ansell, J., Eds. Lexington, (1983) pp. 71-79.
Simonelli, A. P. et al. "Preparation and Evaluation of High Energy PVP-Coprecipitates Including Reversion Phenomena", Proceedings of the 2nd International Symposium on Povidone, Digenis, G. A. and Agha, B. J., Eds., Lexington, (1987) pp. 392-401.
Simonelli et al. "Dissolution Rates of High Energy Polyvinylpyrrolidone (PVP)-Sulfathiazole Coprecipitates", J. Pharm. Sci. (1969) 58:538-549.
Simonelli et al. "Dissolution Rates of High Energy Sulfathiazole-Povidone Coprecipitates II: Characterization of Form of Drug Controlling Its Dissolution Rate via Solubility Studies", J. Pharm. Sci. (1976) 58:355-361.
Mayersohn M. et al. "New Method of Solid-States Dispersion for Increasing Dissolution Rates", J. Pharm. Sci. (1966) 55:1323-1324.
Bird, K. D., "Editorial Review: The Use of Spermicide Containing Nonoxynol-9 in the Prevention of HIV Infection", AIDS (1991) 5:791-796.
Louv, W. C. et al. "A Clinical Trial of Nonoxynol-9 for Preventing Gonococcal and Chlamydial Infections", J. Infect. Dis. (1988) 158:518-523.
Niruthisard S. et al. "The Effects of Frequent Nonoxynol-9 Use on the Vaginal and Cervical Mucosa", Sex. Transm. Dis. (1991) 18:176-179.
LaRocca, R. et al. "Microbiology of Povidone-Iodine--An Overview", Proceedings of the International Symposium on Povidone, Digenis, G. A. and Ansell, J., Eds. Lexington, (1983) pp. 101-119.
Winicov, M. et al. "New Low Iodine Products Based on Stabilized Povidone-Iodine Solution", Proceedings of the International Symposium on Povidone, Digenis, G. A. and Ansell, J., Eds. Lexington, (1987) pp. 57-64.
Digenis, G. A. et al. "Studies on the Association of .sup.14 C-Povidone-.sup.131 I-Iodine Complex with Red Blood Cells and Bacterial Membranes", Proceedings of International Symposium on Povidone, Digenis, G. A. and Ansell, J., Eds. Lexington, (1983) pp. 302-311.
Ben-David A. et al. "The Protective Effect of Polyvinylpyrrolidone and Hydroxyethyl Starch on Noncryogenic Injury to Red Blood Cells", Cryobiology (1972) 9:192-197.
Berkelman, R. L. et al. "Increased Bactericidal Activity of Dilute Preparations of Povidone-Iodine Solutions", J. Clin. Microbiol. (1982) 15:635-639.
Polsky, Bruce, et al. "In Vitro Inactivation of HIV-1 by Contraceptive Sponge Containing Nonoxynol-9", Lancet, (1988) 1456.
Digenis Alexander G.
Digenis George A.
Kulkosky Peter F.
University of Kentucky Research Foundation
LandOfFree
Coated products with potent anti-HIV and antimicrobial propertie does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Coated products with potent anti-HIV and antimicrobial propertie, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Coated products with potent anti-HIV and antimicrobial propertie will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1354743