Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Drug delivery
Reexamination Certificate
2011-03-08
2011-03-08
Prebilic, Paul (Department: 3774)
Prosthesis (i.e., artificial body members), parts thereof, or ai
Arterial prosthesis
Drug delivery
C623S001430
Reexamination Certificate
active
07901453
ABSTRACT:
A coated implantable medical device10includes a structure12adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer18of an immunosuppressive agent posited over at least one surface of the structure12. Optionally, the device10can include at least one porous, preferably polymeric layer20posited over the layer18of immunosuppressive agent, and can alternatively or additionally include at least one coating layer16posited on one surface of the structure12, the at least one layer18of immunosuppressive agent being posited in turn on at least a portion of the coating layer16. The porous layer20and the coating layer16each provide for the controlled release of the bioactive material from the device10. The structure12is preferably configured as a coronary stent. The polymer of the porous layer20is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.
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Bates Brian L.
Fearnot Neal E.
Kozma Thomas G.
Osborne Thomas A.
Ragheb Anthony O.
Cook Incorporated
MED Institute, Inc.
Prebilic Paul
Woodard Emhardt Moriarty McNett & Henry LLP
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