Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Preparing granular- or free-flowing enzyme composition
Patent
1995-12-22
1999-03-09
Naff, David M.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Preparing granular- or free-flowing enzyme composition
435175, 435176, 435177, 435180, 435182, 435264, 510320, 510530, C12N 998, C12N 1108, C11D 1000, D06M 1600
Patent
active
058799206
ABSTRACT:
A granular enzyme composition is produced having reduced tendency to form dust and leave a residue, and improved stability and delayed release characteristics. The composition has a core, optionally coated with a vinyl polymer, a layer containing an enzyme and a vinyl polymer and optionally a plasticizer or anti-agglomeration agent, and an outer coating containing a polymer and optionally a low residue pigment and/or lubricant. Preferably, the core is a salt or sugar nonpareil, the vinyl polymer coating the core is polyvinyl alcohol and most preferably partially hydrolyzed polyvinyl alcohol, the vinyl polymer in the enzyme layer is polyvinyl pyrrolidone, and the polymer of the outer coating is polyvinyl pyrrolidone, polyvinyl alcohol which may be partially hydrolyzed, polyethylene glycol or mixtures thereof such as a mixture of polyvinyl pyrrolidone and polyvinyl alcohol or a mixture of polyvinyl pyrrolidone and polyethylene glycol. Preferably, the pigment is titanium dioxide and the lubricant is a nonionic or anionic surfactant such as a linear primary alcohol of a 9-15 carbon atom chain length alkane or alkene or an ethoxylate or ethoxysulfate derivative thereof. The enzyme can be a protease, amylase, lipase, cellulase, xylanase, oxidase, peroxidase or mixtures thereof. The composition may be produced by spray coating in a fluidized bed a solution of the enzyme and vinyl polymer onto the core to form the enzyme layer, and then spray coating in a fluidized bed a solution of polymer on the enzyme layer to form the outer coating.
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Becker Nathaniel T.
Dale Douglas A.
Gaertner Alfred L.
Park Gene
Anderson Kirsten A.
Genencor International Inc.
Naff David M.
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