Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1993-09-29
1995-10-31
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
204299R, G01N 2726, G01N 27447
Patent
active
054626463
ABSTRACT:
Coated capillary electrophoresis columns and methods for their use in electrophoretic separations are disclosed. The coated capillary columns include a length of tubing having an interior surface coated with at least one crosslinked organic multi-valent ionic compound capable of ionic interaction with charged chemical functionalities on the tubing interior surface. Exemplary columns are prepared by crosslinking a multi-functional amine compound with a diexpoxide, alkylating the crosslinked multi-functional amine compound to form a crosslinked quaternary ammonium compound, and then contacting the interior surface of capillary tubing with the crosslinked quaternary ammonium compound.
REFERENCES:
patent: 5181999 (1993-01-01), Wiktorowicz
Tiansong Wang and Richard A. Hartwick, "Capillary modification and evaluation using streaming potential and frontal chromatography for protein analysis in capillary electrophoresis" Journal of Chromatography 594 (1992) 325-334.
Kiyoshi Tsuji & Richard J. Little, "Charged-reversed, polymer-coated capillary column for the analysis of a recombinant chimeric glycoprotein"; Journal of Chromatography, 594 No month available (1992) pp. 317-324.
John E. Wiktorowicz & Joel C. Colburn; "Separation of cationic proteins via charge reversal in capillary electrophoresis"; Electrophoresis 1990 No month available, vol. 11, pp. 769-773.
John K. Towns and Fred E. Regnier; "Polyethyleneimine-bonded phases in the separation of proteins by capillary electrophoresis"; Journal of Chromatography, 516 (1990) No month available pp. 69-78.
Article by Y. J. Yao and S. F. Y. Li; "Capillary Zone Electrophoresis of Basic Proteins with Chitosan as Buffer Additive and as Capillary Coating"; 26 pages no date in article.
Beckman Instruments Inc.
Harder P. R.
Henry Janis C.
May William H.
Niebling John
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