Chemistry: electrical and wave energy – Apparatus – Coating – forming or etching by sputtering
Patent
1994-01-25
1995-09-05
Niebling, John
Chemistry: electrical and wave energy
Apparatus
Coating, forming or etching by sputtering
2041828, C25B 700
Patent
active
054476178
ABSTRACT:
Coated capillary electrophoresis columns and methods for their use in electrophoretic separations are disclosed. The coated capillary columns include a length of tubing having an interior surface having an interconnected polymeric coating. The interconnected polymeric coating includes a hydrophobic polymeric functionality covalently bound to the interior surface and a hydrophilic polymer interconnected with the hydrophobic polymeric functionality. Exemplary columns are prepared by causing a Si-OH reactive compound, having a hydrophobic polymeric functionality, to react with Si-OH functionalities on the interior surface of capillary columns. Then causing a hydrophilic monomer to polymerize in contact with the hydrophobic polymeric functionality forms a coating of interconnecting hydrophilic and hydrophobic polymers.
REFERENCES:
patent: 4680201 (1987-07-01), Hjerten
patent: 5192406 (1993-03-01), Woolley
patent: 5221447 (1993-06-01), Hjerten
patent: 5282941 (1994-02-01), Rose, Jr.
patent: 5322608 (1994-06-01), Karger et al.
Hjerten, Stellan; "High-Performance Electrophoresis Elimination of Electroendosmosis and Solute Adsorption"; Journal of Chromatography; vol. 347 (1985); pp. 191-198.
Article by Fridstrom, Anita. M. and Markides, Karin. E.; "Synthesis of a Bondable Dense Deactivation Layer for Capillary Electrophoresis"; Jan. 1993.
Schmalzing, Dieter, Piggee, Christine A., Foret, Frantisek, Carrilho, Emanuel and Karger, Barry L.; "Characterization and performance of a neutral hydrophilic coating for the capillary electrophoretic separation of biopolymers"; Journal of Chromatography A; vol. 652 (1993); pp. 149-159.
Beckman Instruments Inc.
Delacroix-Muirheid C.
Harder Paul R.
Henry Janis C.
May William H.
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