Coagulation inhibitors

Details Coagulation inhibitors Coagulation inhibitors

1989-01-26

1992-04-21

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424529, 530300, 530350, A61K 3702, C07K 300

Patent

active

051068338

ABSTRACT:
Novel blood coagulation inhibitors are disclosed which are peptide fragments comprising (A) Kunitz-type domain two of lipoprotein-associated coagulation inhibitor which inhibits Factor Xa production and (B) Kunitz-type domains one and two of lipoprotein-associated coagulation inhibitor which inhibits Factor VIIa/TF enzymatic complex formation.

REFERENCES:
patent: 4966852 (1990-10-01), Wun et al.
Day et al., Blood, vol. 76, No. 8 (Oct. 1990), 1538-45.
Girard et al., Nature, vol. 338 (Apr. 1989) 518.
Broze & Miletich, Proc. Nat'l. Acad. Sci. U.S.A. 84, 1886-1890 (1987).
Wun et al., J. Biol. Chem. 263 (13), 6001-6014 (1988).
Broze et al., Blood 71 (2), 335-343 (1988).
Broze et al., Thromb. Res. 48, 253-259 (1987).
Novotny et al., Blood 72 (6), 2020-2025 (1988).
Gebward et al., (1986), "Protease Inhibitors", (Barret & Salvesen eds.) 375-383 as cited in Broze et al. Biochem. vol. 29, No. 33, Aug. 1990, 7539.
Hochstrasser et al., CA 91(25):206327Z (1979).
Sanders et al., Blood, vol. 66, No. 1 (Jul. 1985) 204.
Wachter et al., CA 91 (25): 206328a (1979).
Rudinger, "Peptide Hormones", (ed. JA Parsons 1976) 1-6.

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