Coagulant plasma-protein solution

Details Coagulant plasma-protein solution Coagulant plasma-protein solution

1983-12-14

1985-03-05

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3516

Patent

active

045030391

ABSTRACT:
A coagulant plasma-protein solution obtained by adsorbing stabilized human plasma at least once with 20-40 mg of colloidal silicic acid per gram of plasma protein and separating the adsorbent from the adsorbate, a method of manufacturing the solution, and a pharmaceutical preparation containing the solution and intended for the intravenous treatment of complex disorders of the hemostatic system. The solution is low in fibrinogen and factors XI and XII but otherwise close in composition to the starting material.

REFERENCES:
patent: 3686395 (1972-08-01), Stephan
patent: 3998946 (1976-12-01), Condie et al.
patent: 4081431 (1978-03-01), Stephan et al.
patent: 4272523 (1981-06-01), Kotitschke et al.
Haemostasis and Thrombosis, Edingburgh, London, Melbourne and New York, Churchill Livingstone, 1981, 472-490.
Fresh Frozen Plasma: Effects and Side Effects, Bibliotheca haemat. 46, 189-206, (1980).
Haemostatic Disorders in Massive Transfusion, Bibliotheca haemat. 46, 179-188, (1980).
The Surface-Mediated Initiation of Blood Coagulation and Related Phenomena, in Ogston & Bennett, Haemostasis, 1977, 25-55.
Von H. G. Lasch et al., Verbrauchskoagulopathien (Pathogenese und Therapie), Folia haematologica, Neue Folge, Bd. 6, pp. 325-330, (1961).

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