Coactivation of nuclear receptors

Details Coactivation of nuclear receptors Coactivation of nuclear receptors

2008-04-08

2008-04-08

Rao, Manjunath N. (Department: 1647)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C435S325000, C530S350000

Reexamination Certificate

active

07354728

ABSTRACT:
The invention provides a protein having an amino acid sequence as in SEQ ID 7, 8, 11 or 12, similar proteins, naturally occurring variants and homologous functional equivalents thereof, as well as the use of a polynucleotide encoding such protein, for use in an assay and for use in a method of modulation of transcriptional activity promoted by a responsive nuclear receptor and a coactivator, which coactivator is the mentioned protein and is named COASTER, and which nuclear receptor is preferrably a steroid receptor.

REFERENCES:
patent: 1 074 617 (2001-02-01), None
patent: 97 10337 (1997-03-01), None
patent: 98 30582 (1998-07-01), None
patent: 99 64596 (1999-12-01), None
patent: 01 75067 (2001-10-01), None
Nagase et al. 1998. DNA Research 5:31-39.
McKenna et al. 1999. Endocrine Reviews. 20:321-344.
Watanabe et al. 1997. BBRC 236:140-145.
Nagase, T. et al.: “Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro”; DNA Research, vol. 5, No. 1, Feb. 28, 1998, pp. 31-39.
Meijer, O.C. et al: “Differential Expression and Regional Distribution of Steroid Receptor Coactivators SRC-1 and SRC-2 in Brain and Pituitary”; ENDOCRINOLOGY, vo. 141, No. 6, Jun. 2000, pp. 2192-2199.
Dechering, K. et al: “Estrogen Receptors alpha and beta: Two Receptors of a Kind?”; Current Medicinal Chemistry, vol. 7, No. 5, May 2000, pp. 561-576.
Glass, C.K. et al: “Nuclear receptor coactivators”; Current Opinion in Cell Biology, vol. 9, No. 2, Apr. 1997, pp. 222-232.
Henikoff et al., “Amino acid substitution matrices from protein blocks,” Proc Natl Acad Sci USA 89 (1992) 10915-10919.
Hong et al., “GRIP1, a Transcriptional Coactivator for the AF-2 Transactivation Domain of Steroid, Thyroid, Retinoid, and Vitamin D. Receptors,” Mol Cell Biol 17 (1997) 2735-2744.
Lyttle et al., “Human Estrogen Receptor Regulation in a Yeast Model System and Studies on Receptor Agonists and Antagonists,” Steroid Biochem Biol 42 (1992) 677-685.
Needleman et al., “A General Method Applicable to the Search for Similarities in the Amino Acid Sequence of Two Proteins,” J Mol Biol 48 (1970) 443-453.
Nishikawa et al., “New Screening Methods for Chemicals with Hormonal Activities Using Interaction of Nuclear Hormone Receptor with Coactivator,” Toxicol Appl Pharmacol 154 (1999) 76-83.
Onate et al., “Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily,” Science 270 (1995) 1354-1357.
Paech et al., “Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites,” Science 277 (1997) 1508-1510.
Stam et al., “Genomic Organization, Coding Sequence and Functional Expression of Human 5-HT2and 5-HT1AReceptor Genes,” Eur J. Pharmacol 227 (1992) 153-162.
Zou et al., “Estrogen Receptor β Activates the Human Retinoic Acid Receptor α-1 Promoter in Response to Tamoxifen and Other Estrogen Receptor Antagonists, but Not in Response to Estrogen,” Mol Endocrinol 13 (1999) 418-430.

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