Coacervate-based oral delivery system for medically useful compo

Details Coacervate-based oral delivery system for medically useful compo Coacervate-based oral delivery system for medically useful compo

1987-01-08

1988-12-27

Kight, John

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424456, 424459, 424460, 424461, 424462, 424463, 514 54, 514 59, 514715, 514774, 514776, 514937, 514959, 514963, 514964, A61K 3700

Patent

active

047940000

ABSTRACT:
The present invention provides for an oral drug delivery system based on a two phase liquid coacervate system prepared from water and one or more surfactants selected from anionic, cationic, amphoteric, and non-toxic surfactants, polysaccharides, synthetic polymers and polysorbates and their derivatives, and in which a pharmaceutical component is incorporated. The delivery system may be prepared in the form of a microemulsion as well as other forms including encapuslated microparticles. The claimed oral composition is useful to delivery oral dosage forms of drugs, their salts and derivatives thereof; biologicals, enzymes, and other pharmocologically active compositions. A method to prepare the oral drug delivery system is also disclosed.

REFERENCES:
patent: 4343797 (1982-08-01), Ecanow
patent: 4356167 (1982-10-01), Kelly
patent: 4394372 (1983-07-01), Taylor
patent: 4439424 (1984-03-01), Ecanow et al.
patent: 4448765 (1984-05-01), Ash et al.
patent: 4539204 (1985-09-01), Ecanow et al.
patent: 4547490 (1985-10-01), Ecanow et al.
patent: 4558032 (1985-12-01), Ecanow et al.
Jizomoto, Hiroaki, "Phase Separation Induced in Gelatin-Base Coacenation Systems by Addition of Water-Soluble Nonionic Polymers I: Microencapsulation" CA101(22):198075y.
Iwasaki, Horoshi et al., "Microencapsulation" CA90(8):61260q.

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