Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-08-06
1997-07-15
Burn, Brain M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514359, 514374, 514392, 514397, 514406, 514425, 514825, 514826, 514863, 514916, 514921, A61K 31415
Patent
active
056483732
ABSTRACT:
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.
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Chilton, III Floyd Harold
Hickey Deirdre Mary Bernadette
Winkler James David
Burn Brain M.
Dinner Dara L.
Lentz Edward T.
SmithKline Beecham Corporation
The Johns Hopkins University
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