CoA-IT and PAF inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514359, 514374, 514392, 514397, 514406, 514425, 514825, 514826, 514863, 514916, 514921, A61K 31415

Patent

active

056483732

ABSTRACT:
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.

REFERENCES:
patent: 3021338 (1962-02-01), Bortnick
patent: 4355039 (1982-10-01), Niedballa et al.
patent: 5087634 (1992-02-01), Reitz et al.
patent: 5248689 (1993-09-01), Girard et al.
patent: 5256695 (1993-10-01), Poss
patent: 5338752 (1994-08-01), Hickey et al.
CA 116(25):255613, 19 Mar. 1992, Hickey et al.
CA 82(25):170937W, 1975, Jorgensen.
CA 117(3):26565, 19 Mar. 1992, Hickey et al.
CA 117(11):111 616JA, 19 Mar. 1992, Hickey et al.
CA 115(5):49682, 1991, Meanwell et al.
CA 112(6):42581b, 1989, Duerr.
CA 110(16):141549h, 1986, Schmitz et al.
CA 105(23):20887p, 1986, Lautenschlaeger et al.
Medline 92170539, 1991, Winkler et al.
Medline 911521139, 1991, Winkler et al.
CA 116(13):125547d, 1991, Suguira et al.
CA 115(17):177545a, 1991, Uemura et al.
Ninio et al., Regulation of the COA-Independent Transacylase in Human Neutrophils, Federation of European Biochemical Societies, Jul. 1991, pp. 138-140.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

CoA-IT and PAF inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with CoA-IT and PAF inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and CoA-IT and PAF inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1492592

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.