Co-stimulatory polypeptides

Details Co-stimulatory polypeptides Co-stimulatory polypeptides

2006-01-13

2009-11-03

Ouspenski, Ilia (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S387300, C514S012200, C424S134100

Reexamination Certificate

active

07612170

ABSTRACT:
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.

REFERENCES:
patent: 5475099 (1995-12-01), Knauf et al.
patent: 5512463 (1996-04-01), Stemmer
patent: 5514588 (1996-05-01), Varadaraj
patent: 5580756 (1996-12-01), Linsley et al.
patent: 5605793 (1997-02-01), Stemmer
patent: 5718883 (1998-02-01), Harlan et al.
patent: 5738852 (1998-04-01), Robinson et al.
patent: 5763239 (1998-06-01), Short et al.
patent: 5789228 (1998-08-01), Lam et al.
patent: 5811238 (1998-09-01), Stemmer et al.
patent: 5814473 (1998-09-01), Warren et al.
patent: 5824469 (1998-10-01), Horwitz et al.
patent: 5830696 (1998-11-01), Short
patent: 5830721 (1998-11-01), Stemmer et al.
patent: 5834252 (1998-11-01), Stemmer et al.
patent: 5837458 (1998-11-01), Minushull et al.
patent: 5858776 (1999-01-01), Ostrand-Rosenberg et al.
patent: 5861310 (1999-01-01), Freeman et al.
patent: 5866363 (1999-02-01), Pieczenik
patent: 5876997 (1999-03-01), Kretz
patent: 5925749 (1999-07-01), Mathur et al.
patent: 5928905 (1999-07-01), Stemmer et al.
patent: 5939250 (1999-08-01), Short
patent: 5939300 (1999-08-01), Robertson et al.
patent: 5942430 (1999-08-01), Robertson et al.
patent: 5942607 (1999-08-01), Freeman et al.
patent: 5948666 (1999-09-01), Callen et al.
patent: 5958672 (1999-09-01), Short
patent: 5958751 (1999-09-01), Murphy et al.
patent: 5962258 (1999-10-01), Mathur et al.
patent: 5962283 (1999-10-01), Warren et al.
patent: 5965408 (1999-10-01), Short
patent: 5985646 (1999-11-01), Murphy et al.
patent: 6001574 (1999-12-01), Short et al.
patent: 6004788 (1999-12-01), Short
patent: 6030779 (2000-02-01), Short
patent: 6045802 (2000-04-01), Schlom et al.
patent: 6054267 (2000-04-01), Short
patent: 6057103 (2000-05-01), Short
patent: 6071716 (2000-06-01), Freeman et al.
patent: 6084067 (2000-07-01), Freeman et al.
patent: 6096548 (2000-08-01), Stemmer
patent: 6117679 (2000-09-01), Stemmer
patent: 6130316 (2000-10-01), Freeman et al.
patent: 6132970 (2000-10-01), Stemmer
patent: 6149905 (2000-11-01), Ostrand-Rosenberg et al.
patent: 6165793 (2000-12-01), Stemmer
patent: 6168919 (2001-01-01), Short
patent: 6171820 (2001-01-01), Short
patent: 6174673 (2001-01-01), Short et al.
patent: 6180406 (2001-01-01), Stemmer
patent: 6238884 (2001-05-01), Short et al.
patent: 6653444 (2003-11-01), Freeman et al.
patent: 7094875 (2006-08-01), Punnunen et al.
patent: 2003/0170821 (2003-09-01), Freeman et al.
patent: 2005/0154189 (2005-07-01), Punnonen et al.
patent: 0911396 (1999-04-01), None
patent: 0911396 (1999-05-01), None
patent: 0934999 (1999-08-01), None
patent: WO 94/24267 (1994-10-01), None
patent: WO 95/03408 (1995-02-01), None
patent: WO 95/23859 (1995-09-01), None
patent: WO 97/07205 (1997-02-01), None
patent: WO 97/20078 (1997-06-01), None
patent: WO 97/25410 (1997-07-01), None
patent: WO 97/35957 (1997-10-01), None
patent: WO 97/35966 (1997-10-01), None
patent: WO 97/44361 (1997-11-01), None
patent: WO 97/48416 (1997-12-01), None
patent: WO 97/48717 (1997-12-01), None
patent: WO 97/48794 (1997-12-01), None
patent: WO 98/00526 (1998-01-01), None
patent: WO 98/01581 (1998-01-01), None
patent: WO 98/13485 (1998-04-01), None
patent: WO 98/13487 (1998-04-01), None
patent: WO 98/24799 (1998-06-01), None
patent: WO 98/27230 (1998-06-01), None
patent: WO 98/28416 (1998-07-01), None
patent: WO 98/31837 (1998-07-01), None
patent: WO 98/36080 (1998-08-01), None
patent: WO 98/41622 (1998-09-01), None
patent: WO 98/41623 (1998-09-01), None
patent: WO 98/41653 (1998-09-01), None
patent: WO 98/42832 (1998-10-01), None
patent: WO 98/48034 (1998-10-01), None
patent: WO 98/58085 (1998-12-01), None
patent: WO 99/07837 (1999-02-01), None
patent: WO 99/08539 (1999-02-01), None
patent: WO 99/10472 (1999-03-01), None
patent: WO 99/10539 (1999-03-01), None
patent: WO 99/19518 (1999-04-01), None
patent: WO 99/21979 (1999-05-01), None
patent: WO 99/23107 (1999-05-01), None
patent: WO 99/23236 (1999-05-01), None
patent: WO 99/29902 (1999-06-01), None
patent: WO 96/41402 (1999-08-01), None
patent: WO 99/41368 (1999-08-01), None
patent: WO 99/41369 (1999-08-01), None
patent: WO 99/41383 (1999-08-01), None
patent: WO 99/41402 (1999-08-01), None
patent: WO 99/43839 (1999-09-01), None
patent: WO 99/45154 (1999-09-01), None
patent: WO 99/57128 (1999-11-01), None
patent: WO 99/57271 (1999-11-01), None
patent: WO 99/65927 (1999-12-01), None
patent: WO 00/42560 (2000-07-01), None
patent: WO 00/42561 (2000-07-01), None
patent: WO 00/53744 (2000-09-01), None
patent: WO 00/58517 (2000-10-01), None
patent: WO 01/18204 (2001-03-01), None
patent: WO 02/00717 (2002-01-01), None
Metzler et al., Nature Structural Biol. 1997; 4:527-531.
Kraus et al., UniProt Accession No. O77684; 1998.
Sequence alignment, 6 pages.
Chang, C-C J., et al.,Nature Biotechnology17(8):793-797 (1999).
Crameri, Andreas, et al.,Nature391:288-291 (1998).
Doty , Raymond T. et al., “Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell constimulation,”Journal of Immunology157:3270-3279 (1996).
Faas, S.J., et al.,Journal of Immunology164(12):6340-6348 (2000).
Fargeas, Christine A., et al.,J. Exp. Med.182:667-675 (1995).
Freeman, Gordon J. et al., “Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation,”Science262:909-911 (Nov. 1993).
Guo, Yong, et al.,J. Exp. Med.181(4):1345-1355 (1995).
He, X-S. et al., “Costimulatory protein B7-1 enhances the cytotoxic T cell response and antibody response to hepatitis B surface antigen,” Proc. Natl. Acad. Sci. USA 93:7274-7278 (1996).
Jenkins, Marc K., “The ups and downs of T Cell costimulation,”Immunity1:443-446 (Sep. 1994).
Karandikar, Nitin J. at al., “CTLA-4: a negative regulator of autoimmune disease,”J. Exp. Med., 184:783-788 (Aug. 1996).
Kim, J.J. et al., “Engineering DNA Vaccines via Co-delivery of Co-Stimulatory Molecule Genes,” Vaccine 16(19):1828-1835 (1998).
Kuchroo, V.K. et al.,“B7-1 and B7-2 Costimulatory Molecules Activate Differentially the Th1/Th2 Developmental Pathways: Application to Autoimmune Disease Therapy,” Cell 80:707-718 (1995).
Lazetic, S. et al., “Chimeric co-stimulatory molecules that selectively act through CD28 or CTLA-4 on human t cells,”Journal of Biological Chemistry277(41):38660-38668 (2002).
Linsley, Peter S. et al., “Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors,”Immunity1:793-801 (Dec. 1994).
Linsley, Peter S. et al., “Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation,”J. Exp. Med.173:721-730 (Mar. 1991).
Metzler, W., et al., “Solution Structure of Human CTLA-4 and Delineation of a CD80/CD86 Binding Site Conserved in CD28,” Nature Structural Biology 4(7):527-531 (Jul. 1997).
Parson, K.R., et al., “Cloning of Cattle CD80,” Immunogenetics 49(3):231-234 (1999).
Patten, Phillip at al., “Applications of DNA shuffling to pharmaceuticals and vaccines,”Current Opinion in Biotechnology8:724-733 (1997).
Peach, Robert J. et al., “Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28,”Journal of Biological Chemistry270(86):21181-21187 (1995).
Rennert, P. et al., “The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion,” International Immunology 9(6):805-813 (1997).

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