Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-08-22
2006-08-22
Gambel, Phillip (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S351000, C530S387100, C514S021800, C435S069100
Reexamination Certificate
active
07094875
ABSTRACT:
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.
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Chang Chia-Chun
Lazetic Alexandra L. L.
Leong Steven R.
Punnonen Juha
Gambel Phillip
Kruse Norman J.
Maxygen Inc.
Ouspenski Ilia
Powers Margaret A.
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