Co-precipitates of adenovirus with metal salts

Details Co-precipitates of adenovirus with metal salts Co-precipitates of adenovirus with metal salts

1998-05-21

2000-07-11

Priebe, Scott D.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

4353201, 435455, 435456, A61K 4800, C12N 1512, C12N 15861

Patent

active

060868708

ABSTRACT:
The present invention provides co-precipitates of metal salts and adenoviral vectors containing a transgene. The co-precipitates of the invention exhibit increased efficiency of gene transfer to a target cell relative to adenoviral vectors alone. Methods of making and using the co-precipitates are also provided. A method of delivering cystic fibrosis transmembrane conductance regulator to an individual with CF utilizing a co-precipitate of cationic molecules and adenoviral vectors containing a transgene encoding a CFTR protein is provided.

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