CNTF and IL-6 antagonists

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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Details

530351, 530399, 530402, 424 852, C07K 14475

Patent

active

054709520

ABSTRACT:
Heterodimer proteins comprising a soluble .alpha. specificity determining cytokine receptor component and the extracellular domain of a .beta. receptor component function as CNTF and IL-6 antagonsists.

REFERENCES:
Baumann et al. (Apr. 24, 1993) J. Biol. Chem. 268:8414.
Davis et al. (Jun. 18, 1993) Science 260:1805.
Ip et al. (Jun. 26, 1992) Cell 69:1121.
Kishimoto et al. (Oct. 23, 1992) 258:593.
Murakami et al. (Jun. 18, 1993) Science 260:1808.
Stahl et al. (Apr. 15, 1993) J. Biol. Chem. 268:7628.
Stahl et al. (Aug. 27, 1993) Cell 74:587.
Devos et al. (1991) The EMBO J. 10:2133-2137.

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