CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof,

Details CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof, CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof,

1989-01-18

1990-08-07

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514480, 514512, 514529, 514532, 514540, 514546, 514655, 549 68, 558271, 558272, 558273, 560 24, 560 27, 560 32, 560108, 560115, 560116, 560134, 560139, 564387, A61K 3113, C07C 8706

Patent

active

049468634

ABSTRACT:
The present invention relates to 3-aminomethyl derivatives of indane, dihydrobenzofurane, dihydrobenzothiophene, and indoline, acid addition salts thereof, isomers thereof, methods of preparation, pharmaceutical compositions and method of treating CNS-disorders such as schizophrenia, Parkinson's disease, depression, anxiety, migraine and senile dementia, or in the cure of cardiovascular diseases, by administering such a derivative.

REFERENCES:
patent: 3419560 (1968-12-01), Bernstein et al.
patent: 3886168 (1975-05-01), Himmele et al.
patent: 4057573 (1977-11-01), Haas et al.
patent: 4505932 (1985-03-01), DeBernardis et al.
Gaino et al., Chem. Abs., vol. 88, No. 23, entry #169822x (1978).
Lahiri et al., J. Pharm. Sci., vol. 57 (6), pp. 1013-1016 (1968)
DeBernardis et al., J. Med. Chem., vol. 28 (10), pp. 1398-1404 (1985).
Bogeso et al., J. Med. Chem., vol. 30, pp. 142-150 (1987).
Nichols et al., Chem. Abs., vol. 99, No. 23, entry #194583e (1983).

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