CNS active substituted azetidinone compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514397, 540200, 540354, 540360, 540362, 540363, 548336, A61K 31415, C07D40312, C07D40314

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active

047192070

ABSTRACT:
Substituted azetidinone compounds are provided which have the formula: ##STR1## wherein one of R.sup.1 and R.sup.2 represents a substituted lower alkyl group, an azido group, an amino group, a lower acylamino group, a mercapto group or a lower alkylthio group and the other represents a hydrogen group, or, both represent hydrogen atoms or lower alkyl groups; R.sup.3 represents a hydrogen atom or a group shown by formula: ##STR2## (wherein X represents ##STR3## (wherein R.sup.5 represents a hydrogen atom or a lower alkyl group) and Y represents a hydroxy group, a lower alkoxy group, an amino group, a mono- or di-lower alkylamino group); R.sup.4 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a group shown by formula: --CH.sub.2 CO--A (wherein A represents an amino group or a group shown by formula: ##STR4## (wherein X and Y are as defined above), provided that when R.sup.1 and R.sup.2 are both hydrogen atoms, at least R.sup.4 represents a group other than a hydrogen atom and provided that either R.sup.3 or R.sup.4 represents a group other than a hydrogen atom. The compounds have strong CNS action.

REFERENCES:
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Chemical Abstracts, 85:21078b (1976) [Kamiya et al., Ger. Offen. 2,529,941, 4/8/76].
Chemical Abstracts, 89:129384v (1978) [Wasserman et al., Ger. Offen. 2,747,494, 5/3/78].
Chemical Abstracts, 92:180439f (1980) [D. Boyd et al., Tetrahedron 1979, 35, 1499].
Chemical Abstracts, 94:15455s (1981) [K. Chiba et al., J. Chem. Soc. Chem. Commun., 1980, (16), 770].
Chemical Abstracts, 94:65461m (1981) [Hashimoto et al., U.S. Pat. No. 4,207,234, 6/10/80].

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