CNP analog peptides and their use

Details CNP analog peptides and their use CNP analog peptides and their use

1992-01-31

1995-07-18

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 530324, 530325, 530326, C07K 1400, C07K 14435, A61K 3817, A61K 3816

Patent

active

054341337

ABSTRACT:
Novel peptides represented by the general formula: ##STR1## and physiologically acceptable acid addition salts thereof; where (A) represents H-, H-Gly, H-Lys-Gly, H-Ser-Lys-Gly, H-Leu-Ser-Lys-Gly, H-Gly-Leu-Ser-Lys-Gly, H-ser, H-Ser-Ser, H-Arg-Ser-Ser, H-Arg-Arg-Ser-Ser, H-Leu-Arg-Arg-Ser-Ser, H-Ser-Leu-Arg-Arg-Ser-Ser;
(B) represents H-Cys or Pmp;
(C) represents Phe-, pCl-Phe, pF-Phe, pNO.sub.2 -Phe or Cha;
(D) represents Ile, Val, Aib, tLeu, Gly or Leu;
(E) represents Lys or Arg;
(F) represents Ile, Leu or Met;
(G) represents Ser or Ala;
(H) represents Met or Gln;
(I) represents --OH, -Asn-OH, -Asn-Ser-OH, -Asn-Ser-Phe-OH, -Asn-Ser-Phe-Arg-OH or -Asn-Ser-Phe-Arg-Tyr-OH; and the symbol " . . . " represents a disulfide bond;
provided that 1) .alpha.-hANP, 2) .alpha.-hANP (7-28) and 3) CNP-22 are excluded from the scope of that general formula.
Also disclosed are agents for suppressing the growth of vascular smooth muscle cells that contains those peptides as effective ingredients.

REFERENCES:
Sudoh et al. Biochem. Biophys. Res. Commun. (1990) 168:863-870.
Kangawa et al. Biochem. Biophys. Res. Commun. (1984) 118:131-139.
Mayumi Furuya et al., "C-Type Natriuretic Peptide is a Growth Inhibitor of Rat Vascular Smooth Muscle Cells", Biochmical And Biophysical Research Communications, vol. 177, No. 3, 1991, Jun. 28, 1991, pp. 927-931.
Mayumi Furuya, et al. "C-Type Natriuretic Peptide Inhibits Intimal Thickening After Vascular Injury", Biochemical And Biophysical Research Communications, vol. 193, No. 1, 1993, May 28, 1993, pp. 248-253.
Chemical Abstracts, vol. 113, No. 3, Jul. 16, 1990; Chemical Abstracts, vol. 113, No. 11, Sep. 10, 1990; Chemical Abstracts, vol. 113, No. 23, Dec. 3, 1990.

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