Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Reexamination Certificate
2003-12-03
2010-11-02
Canella, Karen A (Department: 1643)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
C514S008100, C514S023000, C514S025000, C514S042000, C514S053000, C514S054000, C514S062000, C530S322000, C536S123100
Reexamination Certificate
active
07824687
ABSTRACT:
The present invention provides novel clustered multi-antigenic constructs having the structure:and methods for the synthesis thereof. In still another aspect, the present invention provides methods for the treatment of cancer, preferably for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need, an effective amount of any of the inventive constructs as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier.
REFERENCES:
patent: RE3804 (1870-01-01), Longenecker et al.
patent: 5053489 (1991-10-01), Kufe et al.
patent: 5212298 (1993-05-01), Rademacher et al.
patent: 5229289 (1993-07-01), Kjeldsen et al.
patent: 5280113 (1994-01-01), Rademacher et al.
patent: 5376531 (1994-12-01), Anderson et al.
patent: 5421733 (1995-06-01), Nudelman et al.
patent: 5491088 (1996-02-01), Hellerstrom et al.
patent: 5625030 (1997-04-01), Williams et al.
patent: 5660834 (1997-08-01), Kjeldsen et al.
patent: 5679769 (1997-10-01), Danishefsky
patent: 5683674 (1997-11-01), Taylor-Papadimitriou et al.
patent: 5747048 (1998-05-01), Kjeldsen et al.
patent: 5798090 (1998-08-01), Longenecker et al.
patent: 5807559 (1998-09-01), Jondal et al.
patent: 5858994 (1999-01-01), Kretzschmar et al.
patent: 5871990 (1999-02-01), Clausen et al.
patent: 5977081 (1999-11-01), Marciani
patent: 6013779 (2000-01-01), Wong et al.
patent: 6080725 (2000-06-01), Marciani
patent: 6090789 (2000-07-01), Danishefsky et al.
patent: 6222020 (2001-04-01), Taylor-Papadimitriou et al.
patent: 6238668 (2001-05-01), Danishefsky et al.
patent: 6355639 (2002-03-01), Chou et al.
patent: RE38046 (2003-03-01), Longenecker et al.
patent: 6548661 (2003-04-01), Danishefsky et al.
patent: 6660714 (2003-12-01), Danishefsky et al.
patent: 7018637 (2006-03-01), Chong et al.
patent: 7160856 (2007-01-01), Danishefsky et al.
patent: 7531181 (2009-05-01), Danishefsky et al.
patent: 7550146 (2009-06-01), Danishefsky et al.
patent: 7635750 (2009-12-01), Danishefsky et al.
patent: 7645454 (2010-01-01), Danishefsky et al.
patent: 2002/0006900 (2002-01-01), Danishefsky et al.
patent: 2002/0038017 (2002-03-01), Danishefsky et al.
patent: 2003/0153492 (2003-08-01), Danishefsky et al.
patent: 2004/0102607 (2004-05-01), Danishefsky et al.
patent: 2004/0208884 (2004-10-01), Danishefsky et al.
patent: 2010/0081786 (2010-04-01), Danishefsky et al.
patent: 315153 (1989-05-01), None
patent: 341252 (1997-11-01), None
patent: 8-319300 (1996-12-01), None
patent: WO 96/34005 (1996-10-01), None
patent: WO 96/40198 (1996-12-01), None
patent: WO 97/03995 (1997-02-01), None
patent: WO 98/30190 (1998-07-01), None
patent: WO 98/46246 (1998-10-01), None
patent: WO-9852573 (1998-11-01), None
patent: WO 99/15201 (1999-04-01), None
patent: WO-9915201 (1999-04-01), None
patent: WO 99/48515 (1999-09-01), None
patent: WO-9948515 (1999-09-01), None
patent: WO 01/14395 (2001-03-01), None
patent: WO-0165261 (2001-09-01), None
patent: WO-2004011476 (2004-02-01), None
patent: WO-2004050711 (2004-06-01), None
patent: WO-2004060915 (2004-07-01), None
patent: WO-2010006343 (2010-01-01), None
Abstract of Severin et al, Biokhimiya (Moscow), 1973, vol. 38, pp. 583-588.
Sierra and de la Torre, Angewandte Chemie, 2000, vol. 39, pp. 1539-1559.
U.S. Appl. No. 08/457,485, filed Jun. 1, 1995, Taylor-Papadimitriou et al.
Allen et al, “Pursuit of optimal carbohydrate-based anticancer vaccines: preparation of a multiantigenic unimolecular glycopeptide containing the Tn, MBrl, and Lewisγantigens”,J. Am. Chem. Soc., 123:1890-1897, 2001.
Allen, et al., “A Second Generation Synthesis of the MBrl (Globo-H) Breast Tumor Antigen: New Application of the N-Pentenyl Glycoside Method for Achieving Complex Carbohydrate Protein Linkages”, Chem. Eur. J., 6(8): 1366-1375, 2000.
Balcom, B.J. and Petersen, N.O., “Synthesis and Surfactant Behavior of an Unusual Cyclic Triester Based on acis, cis-1, 3, 5-Cyclohexanetriol Headgroup,”Langmuir, 7:2425-2427, 1991.
Bayle, et al., “O-(3-Butenyl) A Stable Blocking Group Removable by Ozonolysis”,Carbohydrate Research, 232: 375-380, 1992.
Bencomo et al., “Synthesis of glycopeptides having clusters ofO-glycosylic disaccharide chains . . . ,”Carbohydrate Research, 116, C9-C12, 1983.
Bilodeau M.T., “Total Synthesis of a Human Breast Tumro Associated Antigen”,J. Am. Chem. Soc., 117:7840-7841, 1995.
Biswas et al., “Construction of carbohydrate-based antitumor vaccines: synthesis of glycosyl amino acids by olefin cross-metathesis”,Tetrahedron Letters, 43:6107-6110, 2002.
Blackwell et al., “New approaches to olefin cross-metathesis”,J. Am. Chem. Soc., 122:58-71, 2000.
Boehm T. et al., “Development of a Novel Silyl Ether Linker for Solid-Phase Organic Synthesis”J. Org. Chem., 61:6498-6499, 1996.
Boon, T., “Toward a Genetic Analysis of Tumor Rejection Antigens,”Adv. Can. Res., 58:177-211, 1992.
Bosse et al., “Linear synthesis of the tumor-associated carbohydrate antigens Globo-H, SSEA-3, and Gb3”,J. Org. Chem., 67:6659-6670, 2002.
Broddefalk, et al., “Preparation of a Glycopeptide Analogue of Type II Collagen—Use of Acid Labile Protective Groups for Carbohydrate Moieties in Solid Phase Synthesis of O-Linked Glycopeptides”,Tetrahedron Letters, NL, Elsevier Science, 37(17): 3011-3014, 1996.
Cabaret, et al., “Amphiphilic Liposaccharides. Synthesis and Reductive Cleavage of C-Allyl, O-Allyl, and O-Butenyl Glycosyl Derivatives”,Carbohydrate Research, 189: 341-348, 1989.
Chan et al., “Polymer-anchored Organosilyl Protecting Group in Organic Synthesis,”J. Chem. Soc., Chem. Commun., 909-911, 1985.
Collins and Ferrier Monosaccharides: Their Chemistry and Their Roles in Natural Products, Publ. by John Wiley & Sons, Ltd., p. 4, 1995.
Commissions on Nomenclature of Organic Chemistry and Physical Organic Chemistry, IUPAC,Pure and Applied Chemistry, 67, 1325 and 1334, 1995.
Danishefsky et al. “Glycals in Organic Synthesis: The Evolution of Comprehensive Strategies for the Assembly of Oligosaccharides and Glycoconjugates of Biological Consequence”Angew. Chem. Int. Ed. Engl., 35:1380-1419, 1996.
Danishefsky et al. “From the Laboratory to the Clinic: A Retrospective on Fully Synthetic Carbohydrate-Based Anticancer Vaccines”Angew. Chem. Int. Ed. Engl., 39:836-863, 2000.
Dermer, G.B., “Another Anniversary for the War on Cancer,”Bio/Technology, 12, 320, 1994.
Deshpande et al., “Strategy in Oligosaccharide Synthesis: An Application to a Concise Total Synthesis of the KH-1 (Adenocarcinoma) Antigen,”J. Am. Chem. Soc., 120, 1600-1614, 1998.
Elofsson and Kihlberg, “Synthesis of Tn and Sialyl Tn Building Blocks for Solid Phase Glycopeptide Synthesis,”Tetrahedron Letters, 36, 7499-7502, 1995.
Elofsson et al., “Preparation of Tn and Sialyl Tn Building Blocks . . . ,”Tetrahedron, 53, 369-390, 1997.
Ezzell, “Cancer “Vaccines”: An Idea Whose Time Has Come?” J. NIH Res, 7, 46-49, 1995.
Finn et al., “MUC-1 Epithelial Tumor Mucin-based Immunity and Cancer Vaccines”Immunol. Rev., 145, 61-89, 1995.
Freshney, R.I., Culture of Animal Cells, A Manual of Basic Techniques, Alan R. Liss, Inc., New York, p. 3-4, 1983.
Fung et al., “Active Specific Immunotherapy of Murine Mammary . . . ,”Cancer Research, 50, 4308-4314, 1990.
Garg et al., “Developments in the Synthesis of Glycopeptides Containing Glycosyl L-Asparagine, L-Serine, and L-Threonine”Adv. Carb. Chem. Biochem., 50, 277-310, 1994.
Gleiter et al., “Synthesis and Properties of Eight-and Ten-Membered Selenaradialenes,”Tetrahedron Letters, 35, 8779-8782, 1994.
Grice et al., “Tuning and Reactivity of Glycosides: Efficient One-pot Oligosaccharide Synthesis,”Synlett, 781-784, 1995.
Iijima, H. and Ogawa, T. “Synthesis of Mucin-type O-Glycosylated Am
Danishefsky Samuel J.
Keding Stacy J.
Canella Karen A
Choate Hall & Stewart LLP
Herschback Jarrell Brenda
Rearick John P.
Sloan-Kettering Institute For Cancer Research
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