Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Containing at least one abnormal peptide link – e.g. – gamma...
Patent
1991-07-01
1993-12-21
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Containing at least one abnormal peptide link, e.g., gamma...
530326, 530327, 530328, 530329, 530345, 5303911, C07K 702
Patent
active
052722538
ABSTRACT:
Targeted drug conjugates which enable a large number of molecules of drug to be directed to a cell by a single molecule of antibody are provided. The invention also provides intermediates for the synthesis of such conjugates and cytotoxic drugs modified in accordance with the cluster concept of the invention.
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Koppel Gary A.
Offord Robin E.
Rose Keith
Scott William L.
Conrad Robert A.
Eli Lilly and Company
Hill Jr. Robert J.
Parrish John E.
Teng Sally
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