Clottable fibrinogen free factor VIII and albumin product and pr

Details Clottable fibrinogen free factor VIII and albumin product and pr Clottable fibrinogen free factor VIII and albumin product and pr

1976-01-22

1977-05-31

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112B, A61K 3514, C07G 700

Patent

active

040270130

ABSTRACT:
Lyophilizable, clottable fibrinogen free, Factor VIII is produced on a commercial scale from a fibrinogen containing Factor VIII concentrate by sequentially, precipitating a major portion of the clottable fibrinogen by the addition of an ethylene oxide-polyoxypropylene block copolymer, clotting the remainder of the clottable fibrinogen by the addition of a small amount of a thrombin mimetic enzyme which does not decrease the potency of the Factor VIII, and adding human albumin to the resultant clottable fibrinogen free Factor VIII to stabilize its potency during lyophilization.

REFERENCES:
kevy, Chem. Abst., vol. 78 (1973), p. 69608g.

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