Clot retractometer

Details Clot retractometer Clot retractometer

1990-04-19

1991-01-22

Warden, Robert J.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing liquid or solid sample

422109, 436 69, 73 54, 73 58, 73 641, G01N 3348

Patent

active

049869647

ABSTRACT:
An instrument for measuring the internal force characteristics of a blood sample (12) during clotting has been developed. The blood sample (12) is held between a cup (10) and a plate (16). The plate (16) is connected to a force displacement transducer (22). As the clot forms, platelets contract and exert an inward pulling force on the plate (16). This inward pulling force is sensed by the transducer (22) which outputs a corresponding voltage signal. The voltage signal is amplified (24) and recorded on strip chart paper (28). The voltage signal (32) can be directly translated into force parameters by first calibrating the instrument with standard weights. It has been found that the maximum force measurements are obtained under controlled temperature, ionic strength and calcium concentration conditions which approximate those of the blood while in the body. A particular feature of the invention includes a water jacket (14) which is used to maintain the temperature of the blood sample (12) at 37.degree. C. (body temperature).

REFERENCES:
patent: 3053078 (1962-09-01), Jewett
patent: 3814585 (1974-06-01), Bailly
patent: 3900290 (1975-08-01), Hornstra
patent: 3905769 (1975-09-01), Carroll et al.
patent: 3918908 (1975-11-01), Moyer et al.
patent: 4105411 (1978-08-01), Biver
patent: 4317363 (1982-03-01), Shen
patent: 4319194 (1982-03-01), Cardinal et al.
patent: 4695956 (1987-09-01), LeVeen et al.
patent: 4849340 (1989-07-01), Oberhardt
patent: 4862384 (1989-08-01), Bujard
patent: 4879432 (1989-11-01), Vieillard
"Blood"; Carr et al; 74, No. 7 399a (Abstracts 1524 and 1525).
"Platelet Contractile Regulation in an Isometric System"; Cohen et al; Nature vol. 246; pp. 36-37; 1973.
"The Structural Properties and Contractile Force of a Clot"; C. J. Jen and L. V. McIntire; Cell Motility 2; pp. 445-455; 1982.
"Peptides and Monoclonal Antibodies Which Bind to Platelet Glycoproteins IIb and/or IIIA Inhibit Clot Retraction"; T. K. Gartner and M. L. Ogilvie; Thrombosis Research 49; 49; pp. 43-53; 1988.
"Platelets and Fibrin Strands During Clot Retraction"; E. Morgenstern, U. Korell & J. Richter; Thrombosis Research 33; pp. 617-623; 1984.
"Ultrastructure of Clots During Isometric Contraction"; I. Cohen, J. M. Gerrard & J. G. White; The Journal of Cell Biology; vol. 93; pp. 775-787; 1982.
"Separable Function of Platelet Release Reaction and Clot Retraction"; Y. Yatomi et al; Biochemical and Biophysical Research Communications 140; pp. 329-334; 1986.
"The Effect of Dextran 70 on the Structure of Plasma-Derived Fibrin Gels"; M. Carr & D. A. Gabriel; Univ. of N.C.; pp. 985-993; 1980.
"Biorheology in the Practice of Medicine: Resonance Thrombography"; H. Hartert; Biorheology 21; pp. 19-32; 1984.

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