Clostridial toxin disease therapy

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

5303891, 5303895, 4241301, 4241571, 4241641, 4241671, C07K 1602, C07K 1612, A61K 39395

Patent

active

057192677

ABSTRACT:
Treating humans and animals intoxicated with a bacterial toxin by administration of antitoxin. Avian antitoxin in an aqueous solution in therapeutic amount that is orally administrable.

REFERENCES:
patent: 5080895 (1992-01-01), Tokoro et al.
Schmidt et al., J. Vet. Med., 36:619, 1989.
Lyerly et al., Infect. Immun., 59:2215, 1991.
Benedict et al., Chpt. 13. Immunoglobulins and Antibody Production in Avian Species in Comparative Immunology, 1966, Blackwell Publishing, Oxford.
Swartz, Anerobic Spore-Forming Baccili:The Clostridia, in Microbiology, 1990, J.B. Lippincott Company, Philadelphia.
C.L. Hatheway, "Toxigenic Clostridia," Clin. Microbiol. Rev., 3:66 (1990).
S. Arnon, "Infant Botulism: Anticipating the Second Decade," J. Infect. Dis., 154:201 (1986).
S. Arnon, "Infant Botulism," Ann. Rev. Med., 31:541, (1980).
K.L. MacDonald et al., "The Changing Epidemiology of Adult Botulism in the United States," Am. J. Epidemiol., 124:794 (1986).
C.O. Tacket et al., "Equine Antitoxin Use and Other Factors That Predict Outcome in Type A Foodborne Botulism," Am. J. Med., 76:794 (1984).
M.N. Swartz, "Anaerobic Spore-forming Bacilli: The Clostridia," in Microbiology, 4th ed., pp. 633-646 (Davis et al., eds.)(J.B. Lippincott, 1990).
S. Arnon et al., "Infant Botulism: Epidemiology and Relation to Sudden Infant Death Syndrome," Epidemiol. Rev., 3:45 (1981).
Connaught Industries Inc., "Botulism Antitoxin Trivalent (Equine)," Package insert.
T.L. Frankovich et al., "Clinical Trial of Botulism Immune Globulin For Infant Botulism," West. J. Med., 54:103 (1991).
M. Balady, "Botulism Antitoxin Fielded For Operation Desert Storm," USAMRDC Newsletter, p. 6 (1991).
P.J. Schwarz et al., "Botulism Immune Globulin For Infant Botulism Arrives--One Year and A Gulf War Later," West. J. Med., 156:197 (1992).
D.R. Peterson et al., "The Sudden Infant Death Syndrome and Infant Botulism," Rev. Infect. Dis., 1:630 (1979).
S. Arnon et al., "Intestinal Infection and Toxin Production by Clostridium botulinum As One Cause of Sudden Infant Death Syndrome," Lancet p. 1273 (17 Jun. 1978).
H.N. Benson et al., "Requirement of Avian C'1 For Fixation of Guinea Pig Complement by Avian Antibody-antigen Complexes," J. Immunol., 87:616 (1961).
Benedict et al., "Immunoglobulins and Antibody Production in Avian Species," in Comparative Immunology, pp. 335-375, (J.J. Marchaloni, ed.)(Blackwell, Oxford, 1966).
Patterson et al., "Antibody Production and Transfer to Egg Yolk in Chickens," J. Immunol., 898:272 (1962).
Carroll et al., "Antibodies to Calf Thymus RNA Polymerase II From Egg Yolks of Immunized Hens," J. Biol. Chem., 258:24 (1983).
Polson et al., "Antibodies to Proteins From Yolk of Immunized Hens," Immunol. Comm., 9:495 (1980).
Delmee et al., "Characterization of Flagella of Clostridium diffcle and Their Role in Serogrouping Reactions," J. Clin. Microbiol., 28:2210 (1990).
Delmee et al., "Virulence of Ten Serogroups of Clostridium difficile in Hamsters," J. Med. Microbiol., 33:85 (1990).
Toma et al., "Serotyping of Clostridium difficle," J. Clin. Microbiol., 26:426 (1988).
Delmee et al., "Serogrouping of Clostridium difficle strains by slide agglutination," J. Clin. Microbiol., 21:323 (1985).
Davies et al., "Detection of Capsule in Strains of Clostridium difficile of Varying Virulence and Toxigenicity," Microbiol. Path., 9:141 (1990).
S.M. Finegold et al., Bailey and Scott's Diagnostic Microbiology, pp. 488-489 (C.V. Mosby Co., 1978).
N.V. Padhye et al., "Production and Characterization of a Monoclonal Antibody Specific For Enterohemorrhagic Escherichia coli of Serotypes 0157:H7 and 026:H11," J. Clin. Microbiol., 29:99 (1990).
D.M. Lyerly et al., "Passive Immunization of Hamsters Against Disease Caused by Clostridium difficle by Use of Bovine Immunoglobulin G Concentrate," Infect. Immun., 59:2215 (1991).
B.R. DasGupta et al., "Purification and Amino Acid Composition of Type A Botulinum Neurotoxin," Toxicon, 22:415 (1984).
B.R. Singh et al., "Molecular Differences Between Type A Botulinum Neurotoxin and its Toxoid," Toxicon, 27:403 (1989).
H. Towbin et al., "Electrophoretic Transfer of Proteins From Polyacrylamide Gels to Nitrocellulose Sheets: Procedure and Some Applications," Proc. Natl. Acad. Sci, USA, 76:4350 (1979).
K. Weber et al., "Proteins and Sodium Dodecyl Sulfate: Molecular Weight Determination on Polyacrylamide Gels and Related Procedures," in The Proteins, 3rd Edition (H. Neurath & R.L. Hill, eds), pp. 179-223, (Academic Press, NY, 1975).
S.B. Carroll et al., "Production and Purification of Polyclonal Antibodies to the Foreign Segment of .beta.-galactosidase Fusion Proteins," in DNA Cloning: A Practical Approach, vol. III, pp. 89-111, (D. Glover, ed), (IRL Press, Oxford, 1987).
B.S. Thalley et al., "Rattlesnake and Scorpion Antivenoms From the Egg Yolks of Immunized Hens," Bio/Technol. 8:934 (1990).
I. Ohishi et al., "Oral Toxicities of Clostridium botulinum Toxins in Response to Molecular Size," Infect. Immun., 16:107 (1977).
B.W. Wren et al., "Antigenic Cross-Reactivity and Functional Inhibition by Antibodies to Clostridium difficle Toxin A, Streptococcus mutans Glucan-Binding Protein, and a Synthetic Peptide," Infect. Immun., 59:3151 (1991).
R.W. Byard, "Possible Mechanisms Responsible For the Sudden Infant Death Syndrome," J. Paediatr. Child Health 27:147 (1991).
M.S. Schreiner, "Infant Botulism: A Review of 12 Years' Experience at the The Children's Hospital of Philadelphia," Pediatrics 87:159 (1991).
J. Stephen et al., Bacterial Toxins, 2d edition, pp. 57-63 (Aspects of Microbiology Series 2, American Society for Microbiology, 1986).
J.K. Chia et al., "Botulism in An Adult Associated With Food-borne Intestinal Infection With Clostridium botulinum," New Eng. J. Med., 315:239 (1986).
Steven S. Arnon, "Infant Botulism," in Textbook of Pediatric Infectious Diseases, 3d ed., pp. 1095-1102, (R.D. Feigen and J.C. Cherry, eds.) (W.B. Saunders, Philadelphia, 1992).
Steven S. Arnon, "Clinical Trial of Human Infant Botulism Immune Globulin," in Botulinum and Tetanus Neurotoxins: Neurotransmission and Biomedical Aspects, (B.R. DasGupta, ed)(Plenum Press, 1992).
Aureli et al., "Two Cases of Type E Infant Botulism Caused by Neurotoxigenic Clostridium butyricum in Italy," J. Infect. Dis., 154:207-211 (1986).
E.J. Bowmer, M.C., M.D., "Preparation and Assay of the International Standards for Clostridium botulinum types A, B, C, D and E Antitoxins," Bul. Wrld. Hlth. Org., 29:701 (1963).
G.M. Thorne et al., "General Characteristics: Nomenclature of Microbial Toxins," in Pharmacology of Bacterial Toxins, In: International Encyclopedia of Pharmacology and Therapeutics, pp. 5-16, (Dorner and Drews, Eds.) (Pergamon Press, Oxford) (1986).
Bartz et al., J. Inf. Disease, 142(3): 439, 1980 (Supplied in 08/255,009).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Clostridial toxin disease therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Clostridial toxin disease therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Clostridial toxin disease therapy will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1784920

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.