Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Patent
1996-03-25
1998-02-03
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
4352876, 4352885, 4352887, 422 681, 422102, C12M 134, C12M 140
Patent
active
057143803
ABSTRACT:
The present invention features a vessel for isolating a target in a sample. The vessel includes at least one reaction chamber, a wash system and an effluent system. The reaction chamber includes a closed cell adapted to receive a support, a sample potentially containing target and at least one first probe, and thereafter being closed. The probe is capable of associating with the support and the target to form a support-probe-target complex and sample debris upon imposition of probe binding conditions within the reaction chamber. A wash system is capable of introducing solutions into the reaction chamber for washing the support to solubilize and suspend sample debris. Upon imposition of wash conditions, solutions are allowed to enter the reaction chamber to solubilize such sample debris. An Effluent system is in communication with the reaction chamber and capable of receiving sample debris and wash solutions. The vessel receives the sample, binds the target, if present, to the support, allows wash solutions to remove sample debris, and removes wash solutions and sample debris through the effluent system, leaving target isolated on the support.
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Collins Mark L.
Curtis John S.
Neri Bruce P.
Ryan Danahey
Amoco Corporation
Beisner William H.
Galloway Norval B.
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