Multicellular living organisms and unmodified parts thereof and – Method of making a transgenic nonhuman animal – Via microinjection of a nucleus into an embryo – egg cell – or...
Patent
1997-01-10
1999-08-31
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Method of making a transgenic nonhuman animal
Via microinjection of a nucleus into an embryo, egg cell, or...
800 14, 800 15, 800 16, 800 17, 435325, C12N 500, C12N 1500, A01K 6700
Patent
active
059455772
ABSTRACT:
An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring, and for production of isogenic CICM cells, including human isogenic embryonic or stem cells. Production of genetically engineered or transgenic mammalian embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
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Cibelli Jose
Golueke Paul
Jerry D. Joseph
Ponce de Leon F. Abel
Robl James
Crouch Deborah
University of Massachusetts as represented by its Amherst Campus
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