Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-11-21
2006-11-21
Shukla, Ram R. (Department: 1632)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100
Reexamination Certificate
active
07138510
ABSTRACT:
Described herein are genes shown to be essential for programmed cell death inC. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally related cell death genes from various organisms; methods and agents for altering (increasing or decreasing) the activity of the cell death-genes and, thus, of altering cell death; and uses therefor. Specifically, two genes shown to be essential for almost all of the cell deaths which occur in the development ofC. elegans, referred to as ced-3 and ced-4, have been cloned, sequenced and characterized.
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Horvitz H. Robert
Shaham Shai
Yuan Junying
Clark & Elbing LLP
Massachusetts Institute of Technology
Shukla Ram R.
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