Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Nucleoproteins – e.g. – chromatin – chromosomal proteins,...
Reexamination Certificate
2005-09-27
2005-09-27
Weber, Jon (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Nucleoproteins, e.g., chromatin, chromosomal proteins,...
C530S350000, C536S023100, C536S023500, C536S024500, C536S023400, C435S069100, C435S320100, C435S252300
Reexamination Certificate
active
06949624
ABSTRACT:
The present invention relates to the discovery of the human nuclear receptor co-repressor gene and the human nuclear receptor co-repressor protein, a molecule that recruits a complex of proteins that alters chromatin structure and mediates transcriptional repression. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
REFERENCES:
patent: 5644045 (1997-07-01), Mandel et al.
patent: 6512103 (2003-01-01), Dairaghi et al.
Mandel et al. “X-linked adrenoleukodystrophy gene and corresponding protein,” Database: GenEmbl, Accession NO:151114, Oct. 7, 1997.
Alignment Result of SEQ ID NO: 2 with SEQ ID NO: 1, align2_1, Database: US-09-632-033B-1.
Dairaghi et al. “Mammalian chemokine reagents,” Database: Issued_Patents_NA, Accession NO: US-08-567-882-3/c, Dec. 8, 1995.
Wang et al., “Nuclear receptor corepressor1” Oct. 16, 2001, Accession NO: O75376, Database: SwissProt_41 (alignment SEQ ID NO: 3).
Wang et al., “Homo sapiens Nuclear receptor corepressor, complete cds” Sep. 1, 1998, Accession NO: AF044209, Database: GenEmbl (alignment SEQ ID NO: 1).
Wang et al., “Homo sapiens Nuclear receptor corepressor, complete cds” Sep. 1, 1998, Accession NO: AF044209, Database: GenEmbl (alignment SEQ ID NO: 1, 3202-3618).
Wang et al., “Homo sapiens Nuclear receptor corepressor, complete cds” Sep. 1, 1998, Accession NO: AF044209, Database: GenEmbl (alignemt SEQ ID NO: 1, 4891-5649).
Wang et al., “Nuclear receptor corepressor1” Oct. 16, 2001, Accession NO: O75376, Database: SwissProt_41 (alignment SEQ ID NO: 3, 988-1126).
Wang et al., “Nuclear receptor corepressor1” Oct. 16, 2001, Accession NO: O75376, Database: SwissProt_41 (alignment SEQ ID NO: 1551-1803).
Horlein et al., “Mus musculus nuclear receptor corepressor mRNA” Oct. 19, 1996, Accession NO: U35312, Database: GenEmbl (alignment ESQ ID NO: 1).
Alland, L., et al. (1997) Role for N-CoR and Histone Deacetylase in Sin2-Mediated Transcriptional Repression.Nature387:49-55.
Borrow, J., et al. (1996) The Translocation T(8:16)(P11;P13) Of Acute Myeloid Leukaemia Fuses a Putative Acetyltransferase to the CREB-Binding Protein.Nature Gen.14:33-41.
Brehm, A., et al. (1998) Retinoblastoma Protein Recruits Histone Deacetylase to Repress Transcription.Nature391:597-601.
Chen, J.D. and R.M. Evans (1995) A Transcriptional Co-Repressor That Interacts With Nuclear Hormone Receptors.Nature377:454-457.
Erickson, P., et al. (1996) ETO and AML1 Phosphoproteins Are Expressed in CD34+Hematopoietic Progenitors: Implications for t(8;21) Leukemogenesis and Monitoring Residual Disease.Blood88(5):1813-1823.
Erickson, P., et al. (1992) Identification of Breakpoints in t(8;21) Acute Myelogenous Leukemia and Isolation of a Fusion Transcript,AML1/ETO, With Similarity to Drosophila Segmentation Gene,runt. Blood80(7):1825-1831.
Erickson, P., et al. (1994) The ETO Portion of Acute Myeloid Leukemia t(8;21) Fusion Transcript Encodes a Highly Evolutionarily Conserved, Putative Transcription Factor.Cancer Res.54: 1782-1786.
Evans, R.M. and S.M. Hollenberg (1988) Zinc Fingers: Gilt by Association.Cell52: 1-3.
Feinstein, P., et al. (1995) Identification of Homeotic Target Genes inDrosophila melanogasterIncluding nervy, a Proto-oncogene Homologue.Genetics140: 573-586.
Frank, R., et al. (1995) The AML1/ETO Fusion Protein Blocks Transactivation of the GM-CSF Promoter by AML1B.Oncogene11:2667-2674.
Grignani, F., et al. (1998) Fusion Proteins of the Retinoic Acid Receptor-α Recruit Histone Deacetylase in Promyelocytic Leukaemia.Nature391:815-818.
Gross, C.T. and W. McGinnis (1996) DEAF-1, A Novel Protein That Binds an Essential Region in a Deformed Response Element.EMBO J.15(8):1961-1970.
Heinzel, T., et al. (1997) A Complex Containing N-CoR, mSin2 and Histone Deacetylase Mediates Transcriptional Repression.Nature387:43-48.
Hong, S., et al. (1997) SMRT Corepressor Interacts with PLZF and with the PML-Retinoic Acid Receptor α (RARα) and PLZF-RARα Oncoproteins Associated with Acute Promyelocytic Leukemia.Proc. Natl. Acad. Sci. USA.94:9028-9033.
Horlein, A., et al. (1995) Ligand-Independent Repression by the Thyroid Hormone Receptor Mediated by a Nuclear Receptor Co-repressor.Nature377: 397-403.
Jackson, T., et al. (1997) The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7-SPA and the Corepressors N-CoR or SMRT.Mol. Endocrinology11(6):693-705.
Kagoshima, H., et al. (1993) The Runt Domain Identifies a New Family of Heteromeric Transcriptional Regulators.Trends Genet.9(10):338-341.
Kitabayashi, I., et al. (1998) Interaction and Functional Cooperation of the Leukemia-Associated Factors AML1 and p300 in Myeloid Cell Differentiation.EMBO J.17(11):2994-3004.
Kurokawa, R., et al. (1995) Polarity-Specific Activities of Retinoic Acid Receptors Determined by a Co-repressor.Nature377:451-454.
Laherty, C., et al. (1997) Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression.Cell89:349-356.
Lenny, N., et al. (1995) Functional Domains of the t(8;21) Fusion Protein, AML-1/ETO.Oncogene11:1761-1769.
Lin, R., et al. (1998) Role of the Histone Deacetylase Complex in Acute Promyelocytic Leukaemia.Nature391:811-814.
Look, A.T. (1997) Oncogenic Transcription Factors in the Human Acute Leukemias.Science278:1059-1964.
Magnaghi-Jaulin, L., et al. (1998) Retinoblastoma Protein Represses Transcription by Recruiting a Histone Deacetylase.Nature391:601-605.
Mannervik, M., et al. (1999) Transcriptional Coregulators in Developments.Science284:606-609.
Meyers, S., et al. (1995) The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional Activation.Mol. Cell. Biol.15(4):1974-1982.
Meyers, S., et al. (1996) AML-2 is a Potential Target for Transcriptional Regulation by the t(8;21) and t(12;21) Fusion Proteins in Acute Leukemia.Oncogene13: 303-312.
Miyoshi, H., et al. (1993) The t(8;21) Translocation in Acute Myeloid Leukemia Results in Production of an AML1-MTG8 Fusion Transcript.EMBO J.12(7):2715-2721.
Miyoshi, H., et al. (1991) t(8;21) Breakpoints on Chromosome 21 in Acute Myeloid Leukemia are Clustered Within a Limited Region of a Single Gene,AML1. Proc. Natl. Acad. Sci. USA88: 10431-10434.
Nagy, L., et al. (1997) Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase.Cell89:373-380.
Ogryzko, V., et al. (1996) The Transcription Coactivators p300 and CBP are Histone Acetyltransferases.Cell87:953-959.
Okuda, T., et al. (1996) AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia is Essential for Normal Fetal Liver Hematopoiesis.Cell84:321-330.
Owens, G., et al. (1991) Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes,Mol. Cell. Biol.11(8):4177-4188.
Redner, R., et al. (1999) Chromatin Remodeling and Leukemia: New Therapeutic Paradigms.Blood94(2):417-428.
Wang, J., et al. (1997) Transformation Properties of the ETO Gene, Fusion Partner in t(8;21) Leukemias.Cancer Res.57:2951-2955.
Wang, J., et al. (1999) Inhibitors of Histone Deacetylase Relieve ETO-Mediated Repression and Induce Differentiation of AML1-ETO Leukemia Cells.Cancer Research59:2766-2769.
Wang, J., et al. (1998) ETO, Fusion Partner in t(8;21) Acute Myeloid Leukemia, Represses Transcription by Interaction with the Human N-CoR/mSin3/HDAC1 Complex.Proc. Natl. Acad. Sci. USA95:10860-10865.
Wang, Q., et al. (1996) The CBFβ Subunit is Essential for CBFα2 (AML1) Function In Vivo.Cell87:697-708.
Yang, X., et al. (1996) A p300/CBP-Associated Factor That Competes With the Adenoviral Oncoprotein E1A.Nature382:319-324.
Yergeau, D., et al. (1997) Embryonic Lethality and Impairment of Haematopoiesis in Mice Heterozygous For an AML1-ETO Fusion Gene.Nature Gen.15: 303-306.
Liu Johnson M.
Wang Jianxiang
Knobbe Martens Olson & Bear LLP
Mitra Rita
The United States of America as represented by the Department of
Weber Jon
LandOfFree
Cloning of the human nuclear receptor co-repressor gene does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cloning of the human nuclear receptor co-repressor gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloning of the human nuclear receptor co-repressor gene will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3368300