Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-03-09
1996-06-11
Sidberry, Hazel F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 536 2432, 4241851, 4241841, 4242541, 435 691, 435 693, 435 711, 4351721, 530350, C07H 2102, C07H 2104, C12P 2106, A61K 3910
Patent
active
055254896
ABSTRACT:
A cloned DNA fragment of Bordetella pertussis including the gene which codes for the pilinic subunit fim3, vectors which contain it and microorganisms transformed by the vectors.
The protein and peptides corresponding to at least one epitope of the gene which codes for the pilinic subunit fim3 are particularly useful for the development of acellular anti-pertussis vaccines.
In addition, a strain of Bordetella modified by a recombinant replication or genome-integration vector containing the cloned DNA fragment or the gene or a fraction thereof is particularly suitable for the development of a cellular anti-pertussis vaccine.
REFERENCES:
Livey et al, Molecular Microbiology 1981(2) 203-209 Cloning, & Nucleotide Sequence Analysis of the Serotype 2 Fiberbrad Subunit Gene of Bordeletta pertussis.
Suggs et al PNAS 78:6613-6617 1987 Use of Synthetic Oligonucleotides as Hyberdezolion Probes: Isolotosicy Clone cDNA Sequences for human B2-Microglobalin.
Maniatis et al. 1982 Cold Spring Harbor Laboratory Molecular Cloning, a Laboratory Manual see especially Sectors 1, 7, 8, 9, 10, 12.
Cuzzoni et al Nucleic Acids Res 18:1640 Nucleotide Sequence of the fim3 gene from Bordeletta pertussis & Homology to fim3 & fimx Gene Products.
de Ferra et al Tokai J. Exp Clin. Med 13:235-237 1988, Bordetella pertussis Plin and Pilinteke Genes.
Moo's et al Microbial Pathogenesis 2: 473-484 1981 Characterization of Fimbral Subunits from Bordetella Species.
Livey et al, Molecular Microbiology 1: 203-209 1987 Cloning & Nucleotide Sequence Analysis of the Serotype 2 fimboral Subunit Gene of Bordeletta pertussis.
Maniates et al 1982 Cold Spring Harbor, Laboratory of Molecular Cloning, a Laboratory Manual see sections 1, 7, 10, 12.
Cuzzoni Anna
De Ferra Francesca
Grandi Guido
Pedroni Paola
Riboli Barbara
Eniricerche S.p.A.
Sidberry Hazel F.
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