Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-06-07
1999-02-02
Ketter, James
Chemistry: molecular biology and microbiology
Vector, per se
C12N 1500
Patent
active
058664106
ABSTRACT:
The present invention describes a purified and isolated nucleic acid molecule which encodes for the biosynthetic pathway of tetracycline, chlortetracycline or an analogue thereof. The invention relates to the isolation and cloning of the nucleic acid molecule in an isolated fragment from Streptomyces aureofaciens and the expression of the biosynthetic gene in a heterologous host such as Streptomyces lividans.
REFERENCES:
patent: 4921801 (1990-05-01), Rao et al.
patent: 4935340 (1990-06-01), Baltz et al.
patent: 4992371 (1991-02-01), Wohllenben et al.
Old, R.W. and Primrose, S.B. Principles of Gene Manipulation. Blackwell Scientific Publications, Oxford, 1985.
Sambrooke et al. Molecular cloning. A laboratory Manual. pgs. 3.5 and 3.6 Cold Spring Harbor Laboratory Press 1989.
Reynes wt al. 1988 J. Gen Micro. 134 p. 585-598.
Butler et al. 1989 Mol. Gen Genet 215 p. 231-238.
Stanzak et al. Bio/Technology Vol. 4 p. 229-232.
Fantini Susan E.
Lotvin Jason A.
Ryan Michael J.
Strathy Nancy
American Cyanamid Company
Ketter James
Rosenblum Anne M.
Yucel Irem
LandOfFree
Cloning of the biosynthetic pathway for chlortetracycline and te does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cloning of the biosynthetic pathway for chlortetracycline and te, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloning of the biosynthetic pathway for chlortetracycline and te will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1116615