Cloning of the bioA, bioD, bioF, bioC and BioH genes of bacillus

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

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4352523, 43525233, 4351723, 4353201, 435119, 536 27, C12N 1531, C12N 1552, C12N 1563, C12N 121

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active

050968238

ABSTRACT:
The present invention relates, in particular, to a DNA sequence corresponding to one of the following genes involved in the chain of biotin biosynthesis in bacteria: bioA gene, bioD gene, bioF, bioC and bioH gene.
Vectors containing these sequences enable other microorganisms to be transformed in order to improve the production of biotin.

REFERENCES:
J. P. Watson et al., Molecular Biology of the Gene, p. 205, 4th Edition, 1987.
Mountain et al., Cloning of a Bacillus sellis restrictor fragment complementary autotophic mutants of eight E. coli genes of org. biosyn., MGG 197: 82-89, 1984.
Gupta et al.; Elsevier/North-Holland Biomedical Press, Gene, vol. 1, 1977, pp. 331-345; Isolation & Characterization of the Biotin Genes of Escherichia Coli K-12.
Izumi et al.; Agri. Biol. Chem., vol. 45, No. 9, 1981, pp. 1983-1989; Characterization of Biotin Biosxynthetic Enzymes of Bacillus Sphaericus: A Dethiobiotin Producing Bacterium.
Sancar et al.; J. Mol. Biol., vol. 148, 1981, pp. 63-76; Identification of the UVR B Gene Product.
Chemical Abstract; vol. 93, No. 7, Aug. 18, 1980; p. 480; Construction and Characterization of a Recombinant Plasmid Containing . . . Genes of E. Coli K12.
Chemical Abstracts; vol. 90, No. 9, Feb. 26, 1979, p. 250; Isolation and Characterization of a ColE1 Plasmid Containing the Entire Bio Gene Cluster of Escherichia Coli K12.
Chemical Abstracts; vol. 106, No. 3, Jan. 19, 1987; p. 209; Recombinant Plasmids Containing Biotin Synthetase Gene.

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