Cloning of the Babesia bovis 60 KD antigen

Details Cloning of the Babesia bovis 60 KD antigen Cloning of the Babesia bovis 60 KD antigen

1990-04-04

1992-12-15

Ellis, Joan

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 693, 435 31, 4351723, 4352523, 4353201, 536 27, 530350, 935 18, 935 31, 935 41, 935 58, 935 63, 935 73, 935 81, C12N 121, C12N 1500, C12P 2102, C12P 1934

Patent

active

051716852

ABSTRACT:
The subject invention concerns the identification of novel merozoite surface proteins of Babesia bovis. Also disclosed are monoclonal antibodies to these proteins as well as genes which encode for the proteins.
The invention further concerns the use of the novel proteins, recombinant DNA clones, and monoclonal antibodies in the detection, treatment, and prophylaxis of babesiosis.

REFERENCES:
patent: 4762711 (1988-08-01), Buening et al.
Gill et al Mol Biochem Parasitol. vol. 22 pp. 195-202 (1987).
Smith, D. D., M. A. James, M. Ristic, M. Aikawa, and C. A. Vega Y Murgula (1981) "Bovine Babesiosis: Protection of cattle with culture-derived soluble Babesia bovis antigen," Science 212:335-338.
Wright, I. G., B. V. Goodger, K. Rode-Bramanis, J. S. Matlick, D. F. Mahoney, and D. J. Waltisbuhl (1983) "The characterisation of an esterase derived from Babesia bovis and its use as a vaccine," Z. Parasitenkd. 69:703-714.
Wright, I. G., G. B. Mirre, K. Rode-Bramanis, M. Chamberlain, B. V. Goodger, and D. J. Mahoney (1985) "Protective vaccination against virulent Babesia bovis with a low molecular-weight antigen," Infect. Immun. 48:109-113.
Commins, M. A., B. V. Goodger, and I. G. Wright (1985) "Proteinases in the lysate of bovine erythrocytes infected with Babesia bovis: Initial vaccination studies," Int. J. Parasitol. 15:491-495.
Wright, I. G., and P. W. Riddles (1986) "Biotechnological Control of Tick-Borne Disease," Meeting of the Food and Agriculture Organization of the United Nations, Oct. 6-10, 1986, Rome, Italy, pp. 1-21.
Waltisbuhl, D. J., B. V., Goodger, I. G. Wright, G. B. Mirre, and M. A. Commins (1987) "Babesia bovis: Vaccination studies with three groups of high molecular weight antigens from lysate of infected erythrocytes," Parasitol. Res. 73:319-323.
Goff, W. L., W. C. David, G. H. Palmer, and T. C. Mcguire (1988) "Identification of Babesia bovis Merozoite Surface Antigens by Using Immune Bovine Sera and Monoclonal Antibodies," Infect. Immun. 56:2363-2368.
McElwain, T. F., L. E. Perryman, W. C. Davis and T. C. McGuire (1987) "Antibodies define multiple proteins with epitopes exposed on the surface of live Babesia bigemina merozoites," J. Immunol. 138(7):2298-2304.
Cowman, A. F., P. Timms, and D. J. Kemp (1984) "DNA polymorphisms and subpopulations in Babesia bovis," Mol. Biochem. Parasitol. 11:91-103.
Gill, A. C. , A. F. Cowman, N. P. Stewart, D. J. Kemp, and P. Timms (1987) "Babesia bovis: Molecular and Biological Characteristics of Cloned Parasite Lines," Exp. Parasitol. 63:180-188.
Montenegro-James, S., M. Toro Benitez, E. Leon, R. Lopez, and M. Ristic (1987) "Bovine babesiosis: induction of protective immunity with culture-derived Babesia bovis and Babesia begemina immunogens," Parasitol. Res. 74:142-150.
Kuttler, K. L., M. G. Levy, M. A. James, M. Ristic (1982) "Efficac of a nonviable culture-derived Babesia bovis vaccine," Am. J. Vet. Res. 43(2):281-284.

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