Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-07-06
1999-12-21
Teng, Sally P.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 530324, C07K 14705
Patent
active
060050748
ABSTRACT:
Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders; including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
REFERENCES:
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Oliveira et al.; "A Common Motif in G-Protein-Coupled Seven Transmembrane Helix Receptors", Journal of Computer-Aided Molecular Design, vol. 7(6), pp. 649-658 (1993).
Yamada, Y. et al., "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase", Molecular Endocrinology, 6(12): 2136-2142, 1992.
Tal, M. et al. "A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia", Biochem and Biophys. Res. Commun., 209(2): 752-759, 1995.
Marchese et al., "Cloning and Chromosomal Mapping of Three Novel Genes, GPR9, GPR10, and GPR14, Encoding Receptors Related to Interleukin 8, Neuropeptide Y, and Somatostain Receptors", Genomics, vol. 29 (2), pp. 335-344 (1995).
Sambrook et al., Molecular Cloning, vol. 3, 16.2-16.30, 17.2-17.28 (1989) Cold Spring Harbor Laboratory Press.
Bergsma Derk
Shabon Usman
Han William T.
King William T.
SmithKline Beecham Corporation
Teng Sally P.
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