Cloning of honey bee allergen

Details Cloning of honey bee allergen Cloning of honey bee allergen

2005-12-13

2010-12-07

Haddad, Maher M. (Department: 1644)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S252300, C435S320100, C435S325000, C435S455000, C536S023100, C536S023500

Reexamination Certificate

active

07846690

ABSTRACT:
The present invention relates to a nucleic acid encoding a polypeptide capable of binding to IgE from subjects allergic to venom of an insect from the order Hymenoptera having a homology of more than 70% to the amino acid sequence of SEQ ID NO: 2, which is the honey bee allergen Api m3 (acid phosphatase). The invention further relates to expression vectors, host cells and polypeptides encoded by the nucleic acid, as well as diagnostic and pharmaceutical uses thereof.

REFERENCES:
patent: 6812339 (2004-11-01), Venter et al.
patent: 7365185 (2008-04-01), Boukharov et al.
patent: 2004/0023291 (2004-02-01), Spertini
patent: 2 341 389 (2000-03-01), None
Metzler et all Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.° Nature Structural Biol. 4:527-531, 1997.
Bork et al. ‘Powers and Pitfalls in Sequence Analysis: The 70% Hurdle.’ Genome Research. 10:398-400, 2000.
Doerks et al. ‘Protein annotation: detective work for function prediction.’ Trends in Genetics. 14:248-250, 1998.
Smith et al. The challenges of genome sequence annotation or “the devil is in the details”. Nat. Biotech.15:1222-1223, 1997.
Brenner S. ‘Errors in genome annotation.’ Trends in Genetics 15:132-133, 1999.
Bowie et al. Decipering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions. Science 247:1306-1310, 1990.
Lerner et al. ‘Tapping the immunological repertoire to produce antibodies of predetermined specificity.’ Nature. 299:593-596, 1982.
Arbesman et al., “Allergenic potency of bee antigens measured by RAST inhibition”,Clinical Allergy, vol. 6, pp. 587-594 (1976).
Barboni et al., “The Purification of Acid Phosphatase from Honey Bee Venom (Apis Mellifica)”,Toxicon, vol. 25, No. 10, pp. 1097-1103 (1987).
Castro et al., “Biochemical properties and study of antigenic cross-reactivity between Africanized honey bee and wasp venom”,J. Invest. Allergol. Clin. Immunol., vol. 4(1), pp. 37-41 (1994).
Dotimas and Hider, “Honeybee Venom”,Bee World, vol. 68(2), pp. 51-70 (1987).
Eich-Wanger and Müller, “Bee sting allergy in beekeepers”,Clinical and Experimental Allergy, vol. 28, pp.1292-1298 (1998).
Elbein, “The role ofN-linked oligosaccharides in glycoprotein function”,TIBTECH, vol. 9, pp. 346-352 (1991).
Gmachl and Kreil, “Bee venom hyaluronidase is homologous to a membrane protein of mammalian sperm”,Proc. Natl. Acad. Sci. USA, vol. 90, pp. 3569-3573 (1993).
Grunwald et al., Database EMBL (Online), Accession No. DQ058012 (Jun. 5, 2005) (XP-002370247).
Grunwald et al., DATABASE UniProt (Online), Accession No. Q4TUB9 (Jul. 19, 2005) (XP-002370414).
Habermann, “Bienen- und Wespenstiche aus medizinischer Sicht”,Allgemeine Deutsche Imkerzeitung(ADIZ), vol. 11, p. 301-304 (1974).
Helbling et al., “Incidence of anaphylaxis with circulatory symptoms: a study over a 3-year period comprising 940 000 inhabitants of the Swiss Canton Bern”,Clin. Exp. Allergy, vol. 34, pp. 285-290 (2004).
Hoffman et al., DATABASE UniProt (Online), Accession No. Q5BLY5 (Apr. 12, 2005) (XP-002370416).
Hoffman et al., DATABASE EMBL (Online), Accession No. AY939855 (Mar. 19, 2005) (XP 002370415).
Hoffman et al., “Allergens inHymenopteravenom XXI. Cross-reactivity and multiple reactivity between fire ant venom and bee and wasp venoms”,J. Allergy Clin. Immunol., vol. 82, No. 5, Part 1, pp. 828-833 (1988).
Hoffman, “Hymenoptera Venom Proteins” inNatural Toxins 2, Eds. Singh and Tu, Plenum Press, New York and London (1996).
Hoffman and Shipman, “Allergens in bee venom”,J. Allergy Clin. Immunol., vol. 58, No. 5, pp. 551-562 (1976).
Hoffman et al., “Allergens in bee venom II. Two new high molecular weight allergenic specificities”,J. Allergy Clin. Immunol., vol. 59, No. 2, pp. 147-153 (1977).
Hunt et al., “A Controlled Trial of Immunotherapy in Insect Hypersensitivity”,The New England Journal of Medicine, vol. 299, No. 4, pp. 157-161 (1978).
International Search Report from International Application No. PCT/EP2005/013397, issued Apr. 6, 2006.
Jacobsen and Hoffman, “Honey-bee venom acid phosphatase is a member of the prostatic acid phosphatase family”,J. Allergy Clin. Immunol., vol. 95, pp. 372 (1995).
Kettner et al., “Api m 6: A new bee venom allergen”,J. Allergy Clin. Immunol., vol. 107, No. 5, pp. 914-920 (2001).
Kettner et al., “IgE and T-cell responses to high-molecular weight allergens from bee venom”,Clinical and Experimental Allergy, vol. 29, pp. 394-401 (1999).
King, “Insect Venom Allergens”,Allergy, vol. 28, pp. 84-100 (1990).
King and Spangfort, “Structure and Biology of Stinging Insect Venom Allergens”,Int. Arch. Allergy Immunol., vol. 123, pp. 99-106 (2000).
Kuchler et al., “Analysis of the cDNA for phospholipase A2from honeybee venom glands The deduced amino acid sequence reveals homology to the corresponding vertebrate enzymes”,Eur. J. Biochem, vol. 184, pp. 249-254 (1989).
Kulike, “Zur Struktur und Funktion des Hymenopterenstachels”, Amts- und Mitteilungsblatt der Bundesanstalt für Materialprüfung, vol. 16, pp. 519-550 (1986).
Müller, “New Developments in the Diagnosis and Treatment of Hymenoptera Venom Allergy”,Int. Arch. Allergy Immunol., vol. 124, pp. 447-453 (2001).
Müller, “Recombinant Hymenoptera venom allergens”,Allergy, vol. 57, pp. 570-576 (2002).
Schiavino et al., “Specific ultrarush desensitization in Hymenoptera venom-allergic patients”,Anals of Allergy, Asthma, &Immunology, vol. 92, pp. 409-413 (2004).
Sobotka et al., “Honeybee venom: Phospholipase A as the major allergen”,J. Clin. Allergy Clin. Immunol., vol. 53, p. 103, Abstract No. 96, (1974).
Sobotka et al., “Allergy to insect stings II. Phospholipase A: The major allergen in honeybee venom”,J. Allergy Clin. Immunol., vol. 57, No. 1, pp. 29-40 (1976).
Soldatova et al., DATABASE EMBL (Online), Accession No. AF205594 (Nov. 8, 2005) (XP-002370417).
Soldatova et al., DATABASE UniProt (Online), Accession No. Q336K2, (Dec. 6, 2005) (XP-002370418).
Soldatova, “Biological Activity of Recombinant Bee Venom Allergens Expressed in Baculovirus-infected Cells”,Arbeiten Aus Dem Paul-Ehrlich-Institut, 9thInternational Paul-Ehrlich-Seminar, No. 9, pp. 189-193 (1999).
Soldatova et al., “Superior biologic activity of the recombinant bee venom allergen hyaluronidase expressed in baculovirus-infected insect cells as compared withEscherichia coli”,J. Allergy Clin. Immunol., vol. 101, No. 5, pp. 691-698 (1998).
Soldatova et al., “Molecular Cloning of a New Honeybee Venom Allergen, Acid Phosphatase”,J. Allergy Clin. Immunol., Abstracts, p. S378, Abstract No. 1105 (2000).
Sudowe et al., “Efficacy of recombinant adenovirus as vector for allergen gene therapy in a mouse model of type I allergy”,Gene Therapy, vol. 9, pp. 147-156 (2002).
Vlasak et al., “Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin”,Eur. J. Biochem., vol. 135, pp. 123-126 (1983).
Wypych et al., “Analysis of Differing Patterns of Cross-Reactivity of Honeybee and Yellow Jacket Venom-Specific IgE: Use of Purified Venom Fractions”,Int. Arch. Allergy. Appl. Immunol., vol. 89, pp. 60-66 (1989).

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