Cloning of chicken anemia virus DNA

Details Cloning of chicken anemia virus DNA Cloning of chicken anemia virus DNA

1995-06-07

1999-08-03

Myers, Carla J.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435455, 435348, 435349, 536 2372, 536 2432, 536 2433, C07H 2104, C12N 121, C12N 1585

Patent

active

059324767

ABSTRACT:
Recombinant genetic information (DNA or RNA), comprising a Chicken Anemia Virus (CAV)-specific nucleotide sequence and the use thereof for diagnostics, vaccination or protein production are described. Recombinant CAV protein and the use thereof for diagnostics, vaccination or production of CAV-specific antibodies, and use of CAV-specific antibodies thus obtained, are also described. The cloned complete CAV DNA genome disclosed is representative of CAV in the field, worldwide. By means of PCR with primers derived from the cloned CAV genome, CAV-specific sequences corresponding with or complementary to the nucleotide sequence described can be detected. CAV harbors a specific promoter/enhancer element which regulates the CAV transcriptional activity. Based upon this, a sensitive CAV-specific PCR and a method for validating negative PCR results and for estimating the number of CAV DNA copies present in the analyzed sample have been developed.

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