Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-02-21
2006-02-21
Spector, Lorraine (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S069100, C435S320100, C435S325000, C536S023100, C536S023500
Reexamination Certificate
active
07001720
ABSTRACT:
Parkinson's disease (PD) is a common neurodegenrative disorder with a lifetime incidence of approximately 2 percent. It was recently reported that a PD susceptibility gene is located on the long arm of human chromosome four. The present invention reports the subsequent identification of a mutation in the alpha synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity. The finding of a specific molecular alteration which is causative for PD will permit the detailed understanding of the pathophysiology of the disorder, which will lead to potential therapetuic interventions, as well as a means for diagnosing individuals having an increased risk of developing the disease.
REFERENCES:
patent: 5494794 (1996-02-01), Wallace
patent: WO 9409162 (1994-04-01), None
Xi et al. (1996), Genetic Studies in Alzheimer's Disease with an NACP/alpha-Synuclein Polymorphism, Ann. Neur. 40(2): 207-215.
Bormann et al. (1996), Cloning and Heterologous Expression of the Entire Set of Structural Genes for Nikkomycin Synthesis fromStreptomyces tendaeTu901 inStreptomyces lividans, J. Bacteriology 178(4): 1216-1218.
Kreissig et al. (1996), Expression of peptides encoded by exons in cloned mammalian DNA, Nuc. Acids Res. 24(21): 4358-4359.
Xia et al. (1996), NCBI Accession No. AAC02114, NACP gene product.
Schapira, A.H., “Pathogenesis of Parkinson's Disease;” Bailleres Clinical Neurology, vol. 6, No. 1, Apr. 1997, pp. 15-36.
Jakes, R. et al, “Identification of Two Distinct Synucleins from Human Brain,” FEBS Letters, vol. 345, 1994, pp. 27-32.
Ueda, K. et al, “Molecular Cloning of cDNA Encoding an Unrecognized Component of Amyloid in Alzheimer Disease,” Proc. Natl. Acad. Sci. USA, vol. 90, 1993, pp. 11282-11286.
Chen, X. et al, “The Human NACP/Alpha-Synuclein Gene: Chromosome Assignment to 4q21.3-q22 adn Taql RFLP Analysis,” GENOMICS, vol. 26, No. 2, 1995, pp. 425-427.
Polymeropoulos, M. H. et al, “Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23,” SCIENCE, vol. 274, 1996, pp. 1197-1199.
Maroteaux, L. and Scheller, R. H., “The Rat Brain Synucleins: Family Of Proteins Transiently Associated With Neuronal Membrane,” Molecular Brain Research, vol. 11, 1991, pp. 335-343.
Nussbaum, R.L. et al., “Genetics of Parkinson's Disease,” Human Molecular Genetics, vol. 6, No. 10, 1997, pp. 1687-1691.
Geodert, M., “The Awakening of Alpha-Synuclein,” NATURE, vol. 388, Jul. 17, 1997, pp. 232-233.
Polymeropoulos, M. H. et al, “Mutation in the Alpha-Synuclein Gene Identified in Families with Parkinson's Disease,” SCIENCE, vol. 276, Jun. 27, 1997, pp. 2045-2047.
Duvoisin Roger C.
Johnson William G.
Lavedan Christian
Leroy Elisabeth
Nussbaum Robert L.
Hobbs Ann S.
Lockard Jon M
Spector Lorraine
The United States of America as represented by the Secretary of
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