Cloning LFA-1

Details Cloning LFA-1 Cloning LFA-1

1994-04-06

1998-04-14

Ketter, James

Chemistry: molecular biology and microbiology

Vector, per se

536 235, 536 2431, C12N 1570, C12N 1512

Patent

active

057390320

ABSTRACT:
The present invention discloses a cDNA sequence which encodes the beta-subunit of LFA-1. The present invention further discloses fragments of the cDNA sequence which are capable of recognizing a restriction length polymorphism within the LFA-1 sequence.

REFERENCES:
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Shaw et al. Nature, "Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones" vol. 323, No. 18, pp. 262-264 (Sep. 1986).
Plunkett et al., J. of Immun., "Purification and characterization of the lymphocyte function-accociated-2 (LFA-2) molecule", vol. 136, No. 11, pp. 4181-4187, (Jun. 1, 1986).
Barbosa et al., J. of Immun., "The mapping and somatic cell hybrid analysis of the role of human lymphocyte function-associated antigen-3 (LFA-3) in CTL-target cell interactions", vol. 136 No. 8, pp. 3085-3091, (Apr. 15, 1986).
Wolf et al., Clin. Research, "Monoclonal antibodies to T11, LFA-2, and LFA-3 antigens inhibit binding of human thymotcytes to autologous thymic epithelial cells", vol. 34 No. 2, p. 674A (Apr. 1986).
Krensky et al., Hybridoma Technology in the Biosciences and Medicine, "Human cytolytic T-lymphocyte clones and their function-associated cell surface molecules", Chapter 35, pp. 559-573, copyright 1985.
Gromkowski et al., J. of Immun., "Functional distinctions between the LFA-1, LFA-2, and LFA-3 membrane proteins on human CTL are revealed with trypsin pretreated tartget cells", vol. 134, No. 1, pp. 244-249 (Jan. 1985).
Martin et al., J. of Immun., "Identification and functional characterization of two distinct epitopes on the human T-cell surface protein Tp50", vol. 30, No. 1, pp. 180-185 (Jul. 1983).
Krensky et al., J. of Immun., "LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugations", vol. 132, No. 2, pp. 2180-2182 (Aug. 1983).
Krensky et al., J. of Immun., "The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: surface antigens associated with CTL-target interactions", vol. 131, No. 2, pp. 611-614, (Aug. 1983).
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Sanchez-Madrid, Proc. Acad. Sci., "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3", vol. 79, pp. 7489-7493 (Dec. 1982).

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