Cloning, expression and uses of a novel secreted protein, F-spon

Details Cloning, expression and uses of a novel secreted protein, F-spon Cloning, expression and uses of a novel secreted protein, F-spon

1992-04-02

1994-01-18

Wax, Robert A.

Chemistry: molecular biology and microbiology

Vector, per se

435 691, 4352523, 530395, 530399, 536 235, C12N 1500, C12N 1512, C07H 1700

Patent

active

052799662

ABSTRACT:
This invention provides an isolated vertebrate nucleic acid molecule encoding F-spondin. This invention also provides a probe comprising a nucleic acid molecule of at least 15 nucleotides capable of specifically hybridizing with a sequence included within the sequence of a nucleic acid molecule encoding a F-spondin. This invention provides a host vector system for the production of a F-spondin. This invention provides purified F-spondin and the uses of compositions containing purified F-spondin. This invention further provides a method of attaching nerve cells to a matrix using purified F-spondin. This invention also provides a method of stimulating nerve cell growth using purified F-spondin. This invention further provides a method of regenerating nerve call using purified F-spondin. Finally, this invention provides a pharmaceutical composition for stimulating nerve cell growth comprising an effective amount of purified F-spondin and a pharmaceutically acceptable carrier.

REFERENCES:
O'Shea et al., Neuron, vol. 7, pp. 231-237, Aug., 1991; "Thrombospondin and a 140 kd Fragment Promote Adhesion and . . . ".
Kosfeld et al., J. Biol. Chem., vol. 266, No. 3, pp. 24257-24259, Dec. 25, 1991; "Cell Attachment Activity of the Carboxy-terminal . . . ".
Klar et al., Cell, vol. 69, Apr. 3, 1992; pp. 95-110; "F-Spondin: A Gene Expressed at High Levels in the Floor Plate . . . ".
Frazier, W. A., J. Cell Biol., vol. 105, Aug., 1987; pp. 625-632 "Thrombospondin: A Molecular Adhesive Glycoprotein . . . ".
Jacobson, M. (1991), Developmental Neurobiology, pp. 41-93 (Exhibit B).
Jessell, T. M. and Dodd, J. (1991), Neurodegenerative Disorders: Mechanisms and Prospects for Therapy, pp. 105-126 (Exhibit C).
Jessell, T. M. and Dodd, J. (1992), The Harvey Lectures, 86:87-128 (Exhibit D).

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