Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-05-06
1999-06-15
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435197, 536 221, 536 231, 536 232, 536 235, 536 243, 536 2431, 536 2433, C12Q 168, C12N 918, C07H 1900, C07H 2100
Patent
active
059121203
ABSTRACT:
The invention provides two novel members of the cytochrome P450 2C subfamily of enzymes, designated 2C18 and 2C19. DNA segments encoding these enzymes are also provided. The 2C19 polypeptide represents the principal human determinant of human S-mephenytoin 4'-hydroxylase activity. The invention also provides methods of identifying drugs metabolized by S-mephenytoin 4'-hydroxylase activity. Drugs shown to be metabolized by this activity should in general not be administered to individuals having, or belong to an ethnic group at risk of, a polymorphic deficiency in S-mephenytoin 4'-hydroxylase activity. The invention also provides methods of diagnosing individuals having a polymorphic deficiency.
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De Morais Sonia M.F.
Goldstein Joyce A.
Kim Hyosuk
Patterson Jr. Charles L.
The United States of America as represented by the Department of
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