Cloning and uses of the genetic locus bcl-6

Details Cloning and uses of the genetic locus bcl-6 Cloning and uses of the genetic locus bcl-6

1993-06-09

1997-06-24

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352523, 4353201, 435348, 435365, 435367, 435364, 536 235, 536 2431, C12N 1512, C12N 1579, C12N 1570

Patent

active

056416725

ABSTRACT:
This invention provides an isolated vertebrate nucleic acid molecule the bcl-6 locus. This invention also provides an isolated human nucleic acid molecule of bcl-6 locus. This invention further provides a nucleic acid molecule comprising a nucleic acid molecule of at least 15 nucleotides capable of specifically hybridizing with a sequence included within the sequence of the nucleic acid molecule of bcl-6 locus. This invention provides an isolated vertebrate nucleic acid molecule of bcl-6 operatively linked to a promoter of RNA transcription. This invention provides a vector which comprises the nucleic acid molecule of bcl-6 locus. This invention provides a host vector system for the production of a polypeptide encoded by bcl-6 locus, which comprises the vector of bcl-6 locus in a suitable host. This invention provides a polypeptide encoded by the isolated vertebrate nucleic acid molecule of bcl-6 locus. This invention provides an antibody capable of binding to polypeptide encoded by bcl-6 locus. Finally, this invention provides a method of diagnosing diffuse-type B-cell lymphoma in a subject which comprises detecting nucleic acid molecule of bcl-6 locus in a sample from a subject.

REFERENCES:
patent: 5015568 (1991-05-01), Tsujimoto et al.
patent: 5149628 (1992-09-01), Croce
Van Cong et al "The human homologues of Fim1, Fim2/c-Fms, and Fim3,. . . " Hum Genet. 81(3):257-263 (Feb. 1989).
Ye et al "Cloning of bcl-6 . . . " Cancer Res. 53:2732-2735 (15 Jun. 1993).
Rosati et al "Members of the Zinc finger protein gene family . . . " Nuc. Acids Res. 19(20):5661-5667 (Oct. 1990).
Baron et al "Identification of the gene associated with the recurring chromosomal translocations t(3:14)(q27;q32) . . . " PNAS 90:5262-5266 (Jun. 1993).
Cleary et al "Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma . . . " PNAS 82:7439-7443 (Nov. 1985).
Bastard, C., et al. (1992) Translocations involving band 3q27 and Ig gene regions in non-Hodgkin's lymphoma. Blood, 79:2527-2531. (Exhibit B).
Offit, K., et al. (1989) A novel translocation associated with diffuse non-Hodgkin's lymphoma. Blood, 74:1876-1879. (Exhibit C).

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