Cloning and sequencing of the gene which codes for a new pilinic

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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4041841, 4041851, 4042421, 435 691, 435 693, 435 711, 4352532, 43525233, 4353201, 530350, A61K 3902, A61K 3910, C07K 14235, C12N 1500

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056227060

ABSTRACT:
The cloning and sequencing of the gene which codes for a new pilinic subunit of Bordetella pertussis are described. The aminoacid sequence of the mature subunit, deduced from its necleotide sequence, is similar but not identical to that of the known pilins 2, 3 and 6. Polypeptides having the aminoacid sequence of the mature pilinic subunit or of regions thereof are particularly useful for the development of synthetic acellular vaccines against pertussis.

REFERENCES:
Livey et al Mole. Micro 1987 1(2) 203-209.
Cowell et al Int Imn 1987 55: 916-922.
Mooi et al Microb Pathog 2(6) 1987 473-484 (Abs only).
Mooi et al Microb. Pathogen 2: 473-484, 1987.
Pedroni et al Molecular Microbiology 2:539-543, 1988.
Movi et al Microbiol Pattiogenesis 12:127-135 1992.
Livey et al Mol. Microbiol 1:203-209, 1987.
Cowell et al, Infection & Immunity 55:916-922, 1987.
Livey et al Molecular Microbiology 1(2) 203-209 1987 Cloning & Nucleotide sequence analysis of the serotype 2 fimbriol subunit gene of Bordeletta pertussis.
Cowell et al, Infect & Imm. 55:916-922, 1987 Purification & Characterization of Serotype 6 Fimbriae from Bordeletta pertussis & Comparison of their properties with Serotype 2 fimbriae.
Mooi et al Microb Pathog 2(6) 473-484 1987, Abstract only, Characterization of Frimbral subunits from Bordeletta Species.
GRAS-Masse et al Synthetic Peptides in `Biology and Medicine, `pp. 105-112, 1985.
Livey et al Molecular Microbiology 1:203-209 1987.
Cowell et al Infect & Immunity 55:916-922, 1951.
Mooi et al Microb Pathogen. 2:473-484 1987.

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