Cloning and sequencing of the gene which codes for a new pilinic

Details Cloning and sequencing of the gene which codes for a new pilinic Cloning and sequencing of the gene which codes for a new pilinic

1988-12-22

1991-10-22

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 693, 435 91, 4351723, 43525233, 435256, 4353201, 536 27, 530350, 935 9, 935 28, 935 29, 935 37, 935 41, 935 56, 935 65, 935 69, 935 73, 935 74, 935 81, C12N 120, C12N 1500, C12N 118, C12N 1572, C12N 1575, C12N 1581, C12P 2102, C07H 1512, C07K 302

Patent

active

050595377

ABSTRACT:
The cloning and sequencing of the gene which codes for a new pilinic subunit of Bordetella pertussis are described. The aminoacid sequence of the mature subunit, deduced from its necleotide sequence, is similar but not identical to that of the known pilins 2, 3, and 6. Polypeptides having the aminoacid sequence of the mature pilinic subunit or of regions thereof are particularly useful for the development of synthetic acellular vaccines against pertussis.

REFERENCES:
Cuzzoni et al. Nucl. Acids Res.; vol. 18, p. 1640 (1990).
Livey et al. Mol. Micro., vol. 1, pp. 203-209 (1987).

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