Cloning and recombinant production of vespid venom phospholipase

Details Cloning and recombinant production of vespid venom phospholipase Cloning and recombinant production of vespid venom phospholipase

1995-02-08

1997-03-18

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 691, 4353201, 530300, 536 232, 536 235, 536 2431, C12N 920, C12N 1500, A61K 3800, C07H 2104

Patent

active

056122098

ABSTRACT:
The present invention is directed to nucleic acids encoding vespid venom phospholipases, or fragments thereof, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant vectors. The invention is further directed to expression of such nucleic acids to produce recombinant vespid venom phospholipases, or recombinant fragments, derivatives or analogs thereof. Such recombinant products are useful for diagnosis of allergy and for therapeutic treatment of allergy. In specific embodiments, the present invention provides nucleic acids encoding, and complete nucleotide and amino acids sequences for, vespid venom phospholipase A1, for example, Dolichovespula maculata phospholipase A.sub.1 and Vespula vulgaris phospholipase A1.

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