Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-08-23
1998-03-17
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 536 2431, C07H 2104, C12N 1511, C12N 1512
Patent
active
057285454
ABSTRACT:
In accordance with the present invention, there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of .ltoreq.10 nM of CRF occupy .gtoreq.50% of the binding sites of said receptor protein. Nucleic acid sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed. The invention CRF-R can be employed in a variety of ways, such as, for example, in bioassays, for production of antibodies thereto, in therapeutic compositions containing such proteins and/or antibodies.
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Chen Ruoping
Donaldson Cynthia J.
Lewis Kathy A.
Perrin Marilyn H.
Vale, Jr. Wylie W.
Gucker Stephen
Hutzell Paula K.
Reiter Stephen E.
The Salk Institute of Biological Studies
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