Cloning and production of human von willebrand factor GPIb bindi

Details Cloning and production of human von willebrand factor GPIb bindi Cloning and production of human von willebrand factor GPIb bindi

1994-11-30

1998-12-15

Kemmerer, Elizabeth C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 698, 514 8, 514 12, 530324, 530383, 530395, C12N 1563, A61K 3836, C07K 14745

Patent

active

058495363

ABSTRACT:
The subject invention provides non-glycosylated, biologically active polypeptides which comprise the vWF (von Willebrand Factor) GP1b binding domain. These polypeptides may be used to inhibit platelet adhesion and aggregation in the treatment of subjects with conditions such as cerebrovascular disorders and cardiovascular disorders. This invention also provides expression plasmids encoding these polypeptides as well as methods of producing by transforming a bacterial cell and recovering such polypeptides. In addition, the subject invention provides methods of treating and preventing cerebrovascular, cardiovascular and other disorders using these polypeptides to inhibit platelet aggregation.

REFERENCES:
patent: 4620948 (1986-11-01), Builder et al.
patent: 4666884 (1987-05-01), Hawiger, et al.
patent: 5200510 (1993-04-01), Kumar et al.
patent: 5238919 (1993-08-01), Zimmerman et al.
patent: 5321127 (1994-06-01), Handin
patent: 5340727 (1994-08-01), Ruggeri et al.
patent: 5344783 (1994-09-01), Scarborough et al.
patent: 5539086 (1996-07-01), Farb et al.
Pareti et al., J. Biol. Chem. 261(32):15310-15315 (1986) (Exhibit 3).
Fujimura et al., J. Biol. Chem. 262(4):1734-1739 (1987) (Exhibit 4).
Grossi et al., FASEB J. 2(8):2385-2395 (1988) (Exhibit 5).
Mohri et al., CA114:18256lm (1990) (Exhibit 6).
Mancuso et al., J. Biol. Chem. 264(33):19514-19527 (1989) (Exhibit 7).
Carruthers et al., Biochemistry 28:8337-8346 (1989) (Exhibit 8).
Fuster et al., Circulation Res. 51:587-593 (1982) (Exhibit 9).
Kitigawa et al., Cancer res. 49:537-541 (1989) (Exhibit 10).
Karpatkin et al., J. Clin. Invest. 81(4):1012-1019 (1988) (Exhibit 11).
McBride et al., The New England Journal of Medicine 318(26):1734-1737 (1988) (Exhibit 12).
Bellinger et al., P.N.A.S. 84:8100-8104 (1987) (Exhibit 13).
Gralnick et al., P.N.A.S. 89:7880-7884 (1992) (Exhibit 14).
Wick et al., J. Clin. Invest 80:905-910 (1987) (Exhibit 15).
Peterson et al., Blood 69:625-628 (1987) (Exhibit 16).
Yamamoto et al., Thrombosis Res. 39:751-759 (1985) (Exhibit 17).
Harmon et al., Biochemistry 27:2151-2157 (1988) (Exhibit 18).
Sadler, et al., PNAS USA 82:6394-6398 (Oct. 1985).
Girma, et al., Blood, 67:1356-1366, (May 1986).
Houdijk, et al. "Thrombosis and Haemostasis", 56:(3):391-396 (Sep. 1986).
Mohri, et al., J. Biological Chemistry, 264(29):17361-17367, (Oct. 1989).
Sixma, et al., J. Clinical Investigations 74:736-744, (Sep. 1984).
Pietu, et al., Biochem. Biophys. Res. Comm. 164:1339-1347 (Nov. 1989).
Fujimura, et al., J. Biol. Chem. 261:381-385 (Jan. 1986).
Mohri, et al., J. Biol. Chem. 263:17901-17904 (Dec. 1988).
Sugimoto, et al., Abstract No. 2371 in Supplement to Circulation, 82: p. III-597 (Oct. 1990).
Andrews, et al., Biochemistry, 28:8326-8336, (1989).
Sadler et al., Abstract No. 3950 in Federation Proceedings, vol. 44, No. 4, p. 1069 (Mar. 1985).
Lynch et al., Cell, vol. 41, pp. 49-56 (May 1985).
Ginsburg et al., Science, vol. 228, pp. 1401-1406 (Jun. 1985).
Verweij et al., Nucleic Acids Research, vol. 13, No. 13, pp. 4699-4717 (Jul. 1985).
Prior et al., Bio/Technology, vol. 10, pp. 66-73 (Jan. 1992).
Fujimura et al., Abstract No. 1222 in Blood, vol. 66, p. 334a (Nov. 1985).

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