Cloning and production of human von Willebrand Factor GP1b bindi

Details Cloning and production of human von Willebrand Factor GP1b bindi Cloning and production of human von Willebrand Factor GP1b bindi

1995-06-05

1998-11-17

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 514 8, 514 12, 514 13, 514 17, 530324, 530325, 530350, C12P 2106, C12N 120, C12N 1500, A61K 3800

Patent

active

058374884

ABSTRACT:
The subject invention provides non-glycosylated, biologically active polypeptides which comprise the vWF (van Willebrand Factor) GP1b binding domain. These polypeptides may be used to inhibit platelet adhesion and aggregation in the treatment of subjects with conditions such as cerebrovascular disorders and cardiovascular disorders. This invention also provides expression plasmids encoding these polypeptides as well as methods of producing by transforming a bacterial cell and recovering such polypeptides. In addition, the subject invention provides methods of treating and preventing cerebrovascular, cardiovascular and other disorders using these polypeptides to inhibit platelet aggregation.

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