Cloning and identification of the motilin receptor

Details Cloning and identification of the motilin receptor Cloning and identification of the motilin receptor

2007-02-20

2007-02-20

Nickol, Gary B. (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S007100, C435S069100, C435S325000, C435S320100

Reexamination Certificate

active

09719485

ABSTRACT:
The motilin receptor has been isolated and cloned, and nucleic acid sequences are given. Two spice variants have been identified. Also, assays for motilin receptor ligands are given. The identification of the cloned motilin receptor may be used to screen and identify compounds which bind to the receptor for use in a variety of gastric conditions, including gastric motility disorders.

REFERENCES:
patent: 5155218 (1992-10-01), Weinshank et al.
patent: 5712253 (1998-01-01), Lartey et al.
patent: WO 01/32710 (2001-05-01), None
Harigaya et al, Generation of functional clonal cell lines from human bone marrow stroma, Proc. Natl. Acad. Sci. USA, vol. 82, pp. 3477-3480, May 1985.
Depoortere, I et al. “Motilin Receptors of the Rabbit Colon”, PEPTIDES, (1991), vol. 12, pp. 89-94.
Depoortere, I et al. “Distribution and Characterization of Motilin Receptors in the Cat”, PEPTIDES, (1993), vol. 14, pp. 1153-1157.
De Clercq, P. et al. “Isolation, Sequence, and Bioactivity of Chicken Motilin”, PEPTIDES, (1996), vol. 17, No. 2, pp. 203-208.
Poitras, P. et al. “Heterogeneity of Motilin Receptors in the Gastrointestinal Tract of the Rabbit”, (1996), vol. 17, No. 4, pp. 701-707.
Depoortere, I. et al. “Identification of Motilin mRNA in the Brain of Man and Rabbit. Conservation of Polymorphism of the Motilin Gene across Species”. PEPTIDES, (1997), vol. 18, No. 10, pp. 1497-1503.
Coulie, Bernard et al. “Identification of Peptide Ligand-binding Domains within the Human Motilin Receptor Uising Photoaffinity Labeling”. The Journal of Biological Chemistry, (2001), vol. 276, No. 38, pp. 35518-35522.
Smith, Roy G. et al., “Growth Hormone Releasing Substances: Types and Their Receptors”. Hormone Research, (1999), vol. 51, pp. 1-8.
McKee, Karen Kulju et al., “Cloning and Characterization of Two Human G Protein-Coupled Receptor Genes (GPR38 and GPR39) Related to the Growth Hormone Secretagogue and Neurotensin Receptors”, Genomics, Dec. 1997, vol. 46, pp. 426-434.
Palyha, Oksana C. et al., 1998, Database GEN EMBL Submission, Accession No. AF082210.
Feighner, Scott D. et al., “Receptor for Motilin Identified in the Human Gastrointestinal System”, Science, Jun. 1999, vol. 284, pp. 2184-2188.

Affiliated with

Also associated with

Rating

Cloning and identification of the motilin receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cloning and identification of the motilin receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloning and identification of the motilin receptor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3871617