Cloning and expression of the human macrophage inflammatory prot

Details Cloning and expression of the human macrophage inflammatory prot Cloning and expression of the human macrophage inflammatory prot

1993-01-28

1997-07-29

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 231, 536 235, 536 2431, 435 6, 4353201, 435357, 435365, 530350, 530351, C12N 1512, C07K 14705

Patent

active

056521332

ABSTRACT:
This invention provides for the cloning and expression of the human Macrophage Inflammatory Protein-1.alpha. (MIP-1.alpha.)/RANTES Receptor. This receptor binds two cytokines MIP-1.alpha. and RANTES which are pro-inflammatory cytokines. The receptor is useful for assaying the levels of these cytokines in biological specimens. These cytokines play key roles in the inflammatory processes afflicting man.

REFERENCES:
patent: 4985352 (1991-01-01), Julius et al.
Sambrook, J. et al., Molecular Cloning : A Laboratory Manual, Cold Spring Harbor Laboratory Press, 1989, p. 1415.
Gao et al., J. Exp. Med., 177(5): 1421-1427, 1993.
Holmes, W.E. et al., Science, 253: 1278-80, 1991.
Murphy, P.M. et al., Science, 253:1280-1283, 1991.
Rot A. et al., J. Exp. Med., 176:1489-95, Dec. 1992.
Neote, K. et al., FASEB J., 6(5):A2054, abstract 6475, Apr. 1992.

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