Cloning and expression of the full length 110 kDa antigen of...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S300000, C530S825000, C424S190100, C424S234100, C435S069300, C435S071100, C435S320100, C514S002600

Reexamination Certificate

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07371821

ABSTRACT:
The inventive subject matter relates to a recombinant 110 kDa protein fromO. tsutsugamuchi, Karp, Kato and Gilliam strains and for a DNA expression system containing DNA encoding the 110 kDa protein ofO. tsutsugamuchi. The invention also relates to the use of these recombinant contructs in a formulation for the induction of a protective immune response againstO. tsutsugamuchiinvection using. The inventive subject matter also relates to a recombinant 110 kDaO. tsutsugamuchiprotein or 110 kDa fragments for the production of antigen for use in immunodiagnosistic asssays for scrub typhus.

REFERENCES:
patent: 2003/0165523 (2003-09-01), Ching et al.
Oaks et al. Infect. Immun. 55: 1156-1162, 1987.
Mierendorf et al. inNovations 1: 1-3, 1994.

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