Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1993-02-02
1996-08-13
Fleisher, Mindy B.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
536 231, 536 234, 435 6, 4352402, 4352404, 4352542, 4353201, 935 52, C07H 2102, C07H 2104, C12N 510, C12N 1570
Patent
active
055455514
ABSTRACT:
The present invention relates to the PUR protein, nucleotide sequences and expression vectors encoding PUR, and to methods for inhibiting PUR activity. Inhibitors of PUR activity may be used to treat hyperproliferative diseases such as cancer.
REFERENCES:
Wobbe et al., 1987, "Replication of Simian Virus 40 Origin-containing DNA vitro With Purified Protein" Proc. Natl. Acad. Sci. USA 84:1834-1838.
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Vassilev, L. and Johnson, E. M. 1989, "Mapping Initation Sites of DNA Replication in vivo Using Polymerase Chain Reaction Amplification of Nascent Strand Segments" Nucl. Acids Res. 17:7693-7705.
Caddle, M. S. et al., 1990, "Intramolecular DNA Triplexes, Bent DNA and DNA Unwinding Elements in the Initiation Region of an Amplified Dihydrofolate Reductase Replicon"J. Mol. Biol. 211:19-33.
Vassilev, L. and Johnson, E. M. 1990, "An Initiation Zone of Chromosomal DNA Replication Located Upstream of the C-myc Gene in Proliferating HeLa Cells" Mol. Cells. Biol. 10: 4899-4904.
Dailey, L. et al., 1990, "Purification of RIP60 and RIP100, Mammalian Proteins with Origin Specific DNA-binding and ATP-Dependent DNA Helicase Activity" Mol. Cell. Biol. 10:6225-6235.
Caddle, M. S. et al., 1990, "RIP60, a Mammalian Origin-Binding Protein, Enhances DNA Bending Near the Dihydrofolate Reductase Origin of Replication" Mol. Cell. Biol. 10:6236-6243.
Hoffman, J. F. X. and Gasser, S. M., 1991, "Identification and Purification of a Protein that Binds the Yeast ARS Consenus Sequence" Cell64:951-960.
Guiterrez et al., 1991, "Mechanism of Stimulation of DNA Replication by Bacteriophage.o slashed.29 Single-Standed DNA-binding Protein p 5" J. Biol. Chem., 266: 2104-2111.
Erdile et al., 1991, "Characterization of a cDNA Encoding the 70-k-Da Single-stranded DNA-binding Subunit of Human Replication Protein A and the Role of the Protein in DNA Replication" J. Biol. Chem. 266:12090-12098.
Bergemann, A. D. and Johnson, E. M. 1992, "The HeLa PUR Factor Binds Single-Stranded DNA at a Specific Element Conserved in Gene Flanking Regions and Origins of DNA Replications" Mol. Cell. Biol. 12:1257-1265.
Bergemann, A. D. Ma, Z-W and Johnson, E. M. 1992, "Sequence of cDNA Comprising the Human pur Gene and Sequence Specific-Single-Stranded-DNA-Binding Properties of the Encoded Protein" Mol. Cell. Biol. 12:5673-5682.
Bergmann Andrew D.
Johnson Edward M.
Fleisher Mindy B.
Mt. Sinai School of Medicine of the City University of New York
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